The OAIC Biostatistics Core dedicates critically needed resources toward the quantitative challenges of research on frailty. Collaborating in OAIC leadership, and working closely with OAlC Resource, Research Career Development Core (RCDC) and Pilot and Experimental Studies Core (PESC), it aims to: (1) mentor junior scholars supported by our RCDC, PESC and broader OAIC, with the goals of optimizing their: access to data analytic expertise and support;usage of modern database and analytic resources;training in quantitative methods needed to perform high quality research and effectiveness of collaboration with statistical colleagues;(2) provide resources in data infrastructure and emerging computing technologies essential to discovery on frailty, and not possible absent an OAIC or its equivalent;(3) stimulate and advance research on frailty at our institution, by: (a) providing data analytic and management expertise and material support for research on frailty, and (b) developing new methodologies for data analysis needed to conduct basic research on frailty and translate it into clinical practice;and (4) partner with our fellow OAIC Cores, the scholarly community on aging at Johns Hopkins, and with fellow OAICs to advance scholarship on frailty and aging, its translation into effective prevention and intervention strategies, and heighten its visibility. The Core benefits from leadership in these areas that has been long-standing, substantial and wide-reaching. Its situation within this OAIC allows it to provide consultation and collaboration to junior researchers lacking resources. Regarding new methodologies: Research in the coming cycle would be directed to increasing the proof of principle for the hypothesis that dysregulation in multiple physiological systems underpins frailty. By efforts along all these lines, this Core is essential to the success of this OAIC in answering a next generation of questions on frailty, and achieving findings'translation toward increased independence of older persons.

Public Health Relevance

Frailty is a frequent adverse outcome of aging which confers vulnerability to many other adverse outcomes including loss of independence. As a syndrome with a complex etiology, its study poses high data analytic challenges, and research to determine its etiology and methods to ameliorate it require advanced expertise and support. Thus this Core's collaboration in this OAIC is crucial to efforts to improve health and quality of life for millions in our expanding older population

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG021334-12
Application #
8700267
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
$325,062
Indirect Cost
$124,407
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Fitzpatrick, Jessica; Sozio, Stephen M; Jaar, Bernard G et al. (2018) Frailty, body composition and the risk of mortality in incident hemodialysis patients: the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease study. Nephrol Dial Transplant :
Skarupski, Kimberly A; Gross, Alden; Schrack, Jennifer A et al. (2018) The Health of America's Aging Prison Population. Epidemiol Rev 40:157-165
McAdams-DeMarco, Mara A; Ying, Hao; Thomas, Alvin G et al. (2018) Frailty, Inflammatory Markers, and Waitlist Mortality Among Patients With End-stage Renal Disease in a Prospective Cohort Study. Transplantation 102:1740-1746
Walston, Jeremy; Buta, Brian; Xue, Qian-Li (2018) Frailty Screening and Interventions: Considerations for Clinical Practice. Clin Geriatr Med 34:25-38
Wanigatunga, Amal A; Varadhan, Ravi; Simonsick, Eleanor M et al. (2018) Longitudinal Relationship between Interleukin-6 and Perceived Fatigability among well-functioning Adults in mid-to-late Life. J Gerontol A Biol Sci Med Sci :
Walker, Keenan A; Walston, Jeremy; Gottesman, Rebecca F et al. (2018) Midlife Systemic Inflammation is Associated with Frailty in Later Life: The ARIC Study. J Gerontol A Biol Sci Med Sci :
Warsame, Fatima; Ying, Hao; Haugen, Christine E et al. (2018) Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients. Am J Nephrol 48:181-189
Hall, Rasheeda K; McAdams-DeMarco, Mara A (2018) Breaking the cycle of functional decline in older dialysis patients. Semin Dial 31:462-467
Simonsick, Eleanor M; Aronson, Benjamin; Schrack, Jennifer A et al. (2018) Lumbopelvic Pain and Threats to Walking Ability in Well-Functioning Older Adults: Findings from the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc 66:714-720
Martinez-Amezcua, Pablo; Matsushita, Kunihiro; Simonsick, Eleanor M et al. (2018) Fatigability and functional performance among older adults with low-normal ankle-brachial index: Cross-sectional findings from the Baltimore Longitudinal Study of Aging. Atherosclerosis 272:200-206

Showing the most recent 10 out of 251 publications