The Administrative Core (Core A) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center is directed by Dr. Kathleen Welsh-Bohmer, the overall Principal Investigator and Director. The administrative team also includes an Associate Director, James R. Burke, M.D., Ph.D., who also is the Clinical Core Leader, and the Center Administrator, Kathy """"""""Penny"""""""" Sansing-Edwards, who has been with the Center since its inception. The Administrative Core is responsible for the overall direction and oversight of the Center and the optimal utilization of its resources. There are three formal committees necessary for the effective operation of the Center: (1) the Executive Committee composed of the PI, Core Leaders, and Administrator;(2) the Research and Resource Review Committee composed of the PI, Core Leaders, Administrator, and an impartial member from within the Duke community;and (3) the External Advisory Committee. Also, the Bryan ADRC has established strong relationships with local and state agencies, the local Alzheimer's Association chapters, neighboring institutions such as the University of North Carolina at Chapel Hill and the Medical University of South Carolina. The Bryan ADRC is an active participant in the National Alzheimer's Coordinating Center (NACC) and the more recently funded National Cell Repository for AD (NCRAD) initiative. Our Center represents varied scientific disciplines, e.g., neurology, neuropsychology, neurobiology, psychiatry, gerontology, genetics, epidemiology, pharmacogenetics, radiology, which greatly facilitates the Center's success in cross-discipline scientific investigations and the discovery of new and innovative research strategies and findings.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028377-05
Application #
8100405
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$414,381
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Winawer, Melodie R; Griffin, Nicole G; Samanamud, Jorge et al. (2018) Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol 83:1133-1146
Epi4K Consortium; EuroEPINOMICS-RES Consortium; Epilepsy Phenome Genome Project (2017) Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data. Eur J Hum Genet 25:894-899
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Gelfman, Sahar; Wang, Quanli; McSweeney, K Melodi et al. (2017) Annotating pathogenic non-coding variants in genic regions. Nat Commun 8:236
Mori, Mari; Haskell, Gloria; Kazi, Zoheb et al. (2017) Sensitivity of whole exome sequencing in detecting infantile- and late-onset Pompe disease. Mol Genet Metab 122:189-197
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Szabo, Steven T; Harry, G Jean; Hayden, Kathleen M et al. (2016) Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls. Toxicol Sci 150:292-300
Lutz, Michael W; Sundseth, Scott S; Burns, Daniel K et al. (2016) A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease. Alzheimers Dement (N Y) 2:30-44

Showing the most recent 10 out of 110 publications