The overall objective of the Neuropathology Core of the University of Kentucky Alzheimer's Disease Center is to support research on normal brain aging, presymptomatic Alzheimer's disease (AD), mild cognitive impairment (MCI), early and late AD, mixed dementia syndromes, and other dementing disorders. The core will perform short postmortem interval (2-4 hr) autopsies by our Rapid Autopsy Team on longitudinally followed subjects from our normal control BRAiNS Clinic, Dementia Research Clinic, and Kentucky Clinic North Minority Satellite (KYCN), and provide brain specimens, CSF and synaptosomes for investigators at UK, other ADCs, and outside investigators. The core will also provide consensus conference determined diagnoses, quantitation of neurofibrillary tangles (NFT), neuritic plaques, and diffuse plaques from 8 brain regions, Abeta 1-40 and 1-42 quantitation, Braak staging, CERAD, and NIA-Reagan Institute staging on all autopsied cases to investigators. The core will maintain a tissue bank of the above specimens and frozen serum, plasma, buffy coats and CSF from living patients from the Dementia Research Clinic, the normal control BRAiNS Clinic, and KYCN. Special emphasis will be placed on defining the neuropathological findings in the brains of the oldest old (>85), and providing investigators with specimens from cognitively normal control subjects with no Abeta and few NFT (Braak O-ll) (successful cerebral aging) and cognitively normal control subjects with abundant Abeta and NFT. Monthly or more frequent consensus conferences will be held with the Clinical Core to define clinical-pathological diagnoses on all autopsied subjects. Clinical-pathological conferences will be held every two months and twice annually for the Ohio Valley Geriatric Research Center. Support for the Nun Study, the Honolulu Asian Aging study, the UK Udall Parkinson's Disease Research Center and the Georgia Centenarian Study will be provided by the Neuropathology Core. This core's unique opportunity to conduct clinical-pathological correlative studies on longitudinally followed subjects to better understand normal brain aging and the transition to dementia and the factors involved in this transition, could contribute to early interventions and possible preventive measures.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028383-05
Application #
8092611
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$254,052
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Castonguay, David; Dufort-Gervais, Julien; Ménard, Caroline et al. (2018) The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Curr Biol 28:1079-1089.e4
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Al-Janabi, Omar M; Panuganti, Pradeep; Abner, Erin L et al. (2018) Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. J Neuroimaging 28:301-306
Smith, Vanessa D; Bachstetter, Adam D; Ighodaro, Eseosa et al. (2018) Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi. Brain Pathol 28:264-273
Bardach, Shoshana H; Holmes, Sarah D; Jicha, Gregory A (2018) Motivators for Alzheimer's disease clinical trial participation. Aging Clin Exp Res 30:209-212
Bardach, Shoshana H; Schoenberg, Nancy E (2018) The Role of Primary Care Providers in Encouraging Older Patients to Change Their Lifestyle Behaviors. Clin Gerontol 41:326-334
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355

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