PROJECT SUIWMARY The Clinical Translational Resource Core (RC 1) is a key resource for the University of Florida (UF) Older Americans Independence Center (OAIC), providing the infrastructure and expertise for conduding clinical and pre-clinical research across the spedrum of translational investigation. Its primary goal is to encourage and facilitate clinical translational research focused on sarcopenia and disability prevention. The RCI has four Specific Aims: ? Aim 1: To promote and facilitate translation from pre-clinical research and pilot studies into clinical trials in older persons. ? Aim 2: To promote and facilitate the development of pharmacologic, nutritional and behavioral interventions to prevent sarcopenia, and improve physical function and quality of life of older adults. ? Aim 3: To utilize existing data sets and stored biological specimens for secondary analyses to inform and support future clinical trials. ? Aim 4: To provide the research infrastructure, resources, and intellectual environment to facilitate translational research related to sarcopenia and disability prevention. The RCI provides infrastructure and personnel (including UOl and R01 funded investigators) to support the development and implementation of pre-clinical research, pharmacologic, nutritional and behavioral interventions, and observational studies addressing factors contributing to sarcopenia and implications for functional decline and disability. Integrated with the UF Clinical Translational Science Institute (CTSI) as its Aging Clinical Research Unit (Aging CRU) and building on close collaborations with other OAIC cores, the RCI will support pilot/exploratory projects, developmental projects, and external projects. The Core will also provide senior level Investigators with established track records as mentors for career development to lead each of these goals, providing expertise and promoting a rich environment for junior faculty research and senior faculty collaboration.

Public Health Relevance

Age-related decline in physical function and related costs of health care and services pose a major challenge for an aging society. While public health principles encourage evidence -based preventive activities for acute and chronic disease, to date there is no conclusive evidence supporting the efficacy of an intervention to prevent or reverse physical disability in older persons. Research conducted through the UF OAIC seeks to address this gap through its focus on sarcopenia and disability prevention: to improve our understanding of age-related changes in muscle structure and function, explore their impact on fundional impairment and physical disability, as well as develop and test interventions targeting sarcopenia to prevent or reverse impairment, disability, and loss of independence in older populations. The Clinical Translational Resource Core (RCI) builds on pre-clinical, clinical, and epidemiologic research findings to develop and test interventions in pilot/exploratory projects and Phase 2 and 3 clinical trials and takes advantage of ongoing clinical studies to promote translation into basic/mechanistic studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG028740-06
Application #
8206033
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Project Start
Project End
Budget Start
2012-04-15
Budget End
2013-03-31
Support Year
6
Fiscal Year
2012
Total Cost
$202,204
Indirect Cost
$64,181
Name
University of Florida
Department
Type
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Stortz, Julie A; Mira, Juan C; Raymond, Steven L et al. (2018) Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients. J Trauma Acute Care Surg 84:342-349
Datta, Rupak; Trentalange, Mark; Van Ness, Peter H et al. (2018) Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun 9:77-80
Vistamehr, Arian; Balasubramanian, Chitralakshmi K; Clark, David J et al. (2018) Dynamic balance during walking adaptability tasks in individuals post-stroke. J Biomech 74:106-115
Scheidell, Joy D; Quinn, Kelly; McGorray, Susan P et al. (2018) Childhood traumatic experiences and the association with marijuana and cocaine use in adolescence through adulthood. Addiction 113:44-56
Anton, Stephen D; Ebner, Natalie; Dzierzewski, Joseph M et al. (2018) Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study. J Altern Complement Med 24:725-732
Rejeski, W Jack; Walkup, Michael P; Fielding, Roger A et al. (2018) Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability. J Gerontol A Biol Sci Med Sci 73:660-667
Kheirkhahan, Matin; Chakraborty, Avirup; Wanigatunga, Amal A et al. (2018) Wrist accelerometer shape feature derivation methods for assessing activities of daily living. BMC Med Inform Decis Mak 18:124
Mohler 3rd, Emile R; Ellenberg, Susan S; Lewis, Cora E et al. (2018) The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials. J Clin Endocrinol Metab 103:681-688
Loftus, Tyler J; Rosenthal, Martin D; Croft, Chasen A et al. (2018) Effect of Time to Operation on Value of Care in Acute Care Surgery. World J Surg 42:2356-2363
Mora, Juan C; Przkora, Rene; Cruz-Almeida, Yenisel (2018) Knee osteoarthritis: pathophysiology and current treatment modalities. J Pain Res 11:2189-2196

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