The Advanced Genomics of Aging Core (AGAC) will enable Einstein Nathan Shock Center (E-NSC) members to utilize advanced, high-throughput (epi)genomics tools to unravel the molecular genetic underpinnings of age-related loss of physiological homeostasis and their genetic and epigenetic control. In turn, this should greatly facilitate building new geroscience initiatives in translational aging research. Rather than duplicating existing core facilities at our home institution and elsewhere, we decided to leverage the availability of some outstanding Einstein shared facilities, most notably, the Genomics and Epigenomics Cores, the Single-Cell Genomics Core, the Cytogenetics Core and the Computational Genomics Core, to assist investigators in aging more broadly with their advanced genomics studies, providing both expert advice in study design, process flow and analysis, and special services, including single-cell genomics assays. With the AGAC we propose to cut across existing facilities to create a unique Core Resource to serve members and associated members of the proposed E-NSC. We are able to do so by taking advantage of: (1) ongoing research programs at Einstein in the genetics and molecular genetics of human aging and longevity; (2) deep expertise in genomics and epigenomics in the Department of Genetics; and (3) generous Institutional support.

Public Health Relevance

Changes with age in the genome may underlie the basis of some of the fundamental aspects of aging and contribute to a growing number of age-related disorders, in particular to cancer. However, access to highly specialized technology, and its price, limits the potential for discovery. The AGAC will make those accessible to the aging research community and, through the innovation, will contribute to the development and use of new methodology for the study of this fundamental process in the biology of aging.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
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Albert Einstein College of Medicine, Inc
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Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150
Guan, Fangxia; Tabrizian, Tahmineh; Novaj, Ardijana et al. (2018) Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis. Front Nutr 5:37
Tekirdag, Kumsal; Cuervo, Ana Maria (2018) Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone. J Biol Chem 293:5414-5424
Theofilas, Panos; Ehrenberg, Alexander J; Nguy, Austin et al. (2018) Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging 61:1-12
Choi, Jiahn; Rakhilin, Nikolai; Gadamsetty, Poornima et al. (2018) Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging. Sci Rep 8:10989
Sathyan, Sanish; Barzilai, Nir; Atzmon, Gil et al. (2018) Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. Front Med (Lausanne) 5:105
Amengual, Jaume; Guo, Liang; Strong, Alanna et al. (2018) Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100. Circ Res 122:568-582
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Bejarano, Eloy; Murray, John W; Wang, Xintao et al. (2018) Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. Aging Cell :e12777

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