Since 1986, studies on HIV and AIDS pathogenesis conducted at UCLA have relied on a well-run, state-of the-art Virology Core facility. The overall purpose of this facility has been to serve as an accessible resource for development of research techniques for UCLA investigators and their collaborators pursuing basic science, clinical science, public health, and behavioral science research in the field of HIV/AIDS. Reflecting the scientific needs of CFAR investigators on the UCLA campus, the following specific aims are proposed for the Virology Core. 1. To supply a readily available resource for UCLA investigators requiring virological support in the form of assays, technical expertise, primary human cells and/or storage/maintenance of viral specimen inventories. 2. To provide access and appropriate training for use of the Core-maintained BSL2+Tissue Culture/PCR clean facility. 3. To serve as a """"""""wet lab"""""""" resource for behavioral and social science HIV investigators, offering access to routine bioassays and virological assessments. 4. To develop, evaluate and incorporate new procedures, assays, and reagents relevant to the needs of UCLA HIV/AIDS investigators. 5. To foster collaboration, training and development of junior investigators as well as intramural and extramural investigators pursuing collaborative research with UCLA HIV/AIDS investigators. The Virology Core actively promotes the use of all of our assays/services to clinical, basic, public health, and behavioral investigators;currently over 80 Principle Investigators utilize some form of core sen/ice. The goal is to make the Virology Core accessible and readily available to all investigators at UCLA who are studying any aspect of HIV infection, and to continue to foster interactions between investigators of different scientific and clinical disciplines at UCLA, as well as other UCLA-affiliated institutions.

Public Health Relevance

The Virology Core serves as a focal point for the development and application of novel technologies in HIV assessment, and is also the only campus resource for investigators requiring reliable access to primary human hematopoietic cells, including peripheral blood cells and hematopoietic stem cells (umbilical cord blood and bone marrow).

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-UKS-A)
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University of California Los Angeles
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Sun, Jie; He, Xin; Zhu, Yinghui et al. (2018) SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. Cell Stem Cell 23:355-369.e9
Shannon, Chelsea L; Klausner, Jeffrey D (2018) The growing epidemic of sexually transmitted infections in adolescents: a neglected population. Curr Opin Pediatr 30:137-143
Bristow, Claire C; Shannon, Chelsea; Herbst de Cortina, Sasha et al. (2018) Use of Oral Fluid With a Rapid Treponemal Test for Syphilis Evaluation. Sex Transm Dis 45:e65-e67
Withers, Keenan; Bristow, Clare; Nguyen, Minh et al. (2018) A field evaluation of a rapid dual immunoassay for human immunodeficiency virus and syphilis antibodies, Hanoi, Vietnam. Int J STD AIDS :956462418802685
Beymer, Matthew R; DeVost, Michelle A; Weiss, Robert E et al. (2018) Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California. Sex Transm Infect 94:457-462
Bristow, Claire C; Kojima, Noah; Lee, Sung-Jae et al. (2018) HIV and syphilis testing preferences among men who have sex with men and among transgender women in Lima, Peru. PLoS One 13:e0206204
Alban, Tyler J; Alvarado, Alvaro G; Sorensen, Mia D et al. (2018) Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight 3:
Tylee, Daniel S; Sun, Jiayin; Hess, Jonathan L et al. (2018) Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. Am J Med Genet B Neuropsychiatr Genet 177:641-657
Dovel, Kathryn; Shaba, Frackson; Nyirenda, Mike et al. (2018) Evaluating the integration of HIV self-testing into low-resource health systems: study protocol for a cluster-randomized control trial from EQUIP Innovations. Trials 19:498
Degtyar, Aleksandra; George, Paul E; Mallma, Patricia et al. (2018) Sexual Risk, Behavior, and HIV Testing and Status among Male and Transgender Women Sex Workers and their Clients in Lima, Peru. Int J Sex Health 30:81-91

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