Abstract

One of the most important functions of a CFAR is the opportunity to use developmental funds to support innovative new research ideas and new investigators to AIDS research. We have allotted 20% of the total CFAR budget in Yea 1 to developmental support of promising new research. We anticipate that amount will increase in future years, as we plan to direct revenue generated through the charge-back system in the Basic Science and Clinical Cores into the Development Core. Research proposals requesting developmental support will be evaluated for scientific merit by the CFAR Internal Advisory Committee. Other considerations will include the potential for clinical and basic science interactions and the likelihood that the project will lead to new knowledge and the acquisitions of external funding. No projects have been approved for funding at this time, but a number of research abstracts from investigators interested in competing for developmental funds are summarized to illustrate the breadth and quality of new AIDS research the CFAR will be able to facilitate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-04
Application #
6235245
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Zhao, Na; Cao, Jin; Xu, Longyong et al. (2018) Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299
Scavuzzo, Marissa A; Hill, Matthew C; Chmielowiec, Jolanta et al. (2018) Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun 9:3356
Newton, Jared M; Hanoteau, Aurelie; Sikora, Andrew G (2018) Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors. J Vis Exp :
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:
Spencer, Jennifer L; Lahon, Anismrita; Tran, Linda L et al. (2018) Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis 217:538-547
Hong, M J; Gu, B H; Madison, M C et al. (2018) Protective role of ?? T cells in cigarette smoke and influenza infection. Mucosal Immunol 11:894-908
Madan, Simran; Kron, Bettina; Jin, Zixue et al. (2018) Arginase overexpression in neurons and its effect on traumatic brain injury. Mol Genet Metab 125:112-117
Hsu, Joanne I; Dayaram, Tajhal; Tovy, Ayala et al. (2018) PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell 23:700-713.e6
Misra, Anisha; Gleeson, Emile; Wang, Weiming et al. (2018) Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity. J Virol 92:
Byrd, Tiara T; Fousek, Kristen; Pignata, Antonella et al. (2018) TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res 78:489-500

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