The CFAR 1rnmunology Core is designed to provide both state-of-the-art flow cytometric capabilities as well as expertise and technical assistance for numerous immunological assays desired by members of the CFAR. The core is dedicated to providing such service in a timely, cost-effective, and efficient manner. The core is headed by Dr. Dorothy E. Lewis, who has over 20 years of flow and immunologic experience and a staff of well- trained personnel. The core consists of two flow cytometers, an analytical one and a high speed cell sorter, a BL-2 containment room for immunological assays, and a confocal microscope. Cytokine measurement expertise is provided by Dr. Reuben at M.D. Anderson Cancer Center, located across the street from Baylor College of Medicine, on a fee-for- service basis. In the previous funding period, the core has been essential for studies involving immune function in pediatric HW and has facilitated interactions with clinical and basic science researchers. In particular, the core was key for studies of Tat kinase activity in primary lymphocytes, in detection of cytokine messages, and in analysis of CD8+ T cell function in HWinfected children. The core has also developed new assays for the users, including improved HIV-speciflc cytotoxic T lymphocyte assays and cytokine quantitation in tissues. A range of services is provided by this core which include flow cytometry, lymphocyte function assays and confocal microscopy. Training on the use of instrumentation and data interpretation is also a key component of the core. The core will be overseen by a committee. The Core Director will have responsibility for day-to-day running of the core, and priorities for usage are prescribed in a standardized manner mcluding an appropriate charge-back system. It is anticipated that at least 19 investigators at Baylor College of Medicine and at The University of Texas, UTMB-Galveston, Texas A&M University, and Tulane University School of Medicine will benefit. ~

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Baylor College of Medicine
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Kho, Jordan; Tian, Xiaoyu; Wong, Wing-Tak et al. (2018) Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet 103:276-287
Grzeskowiak, Caitlin L; Kundu, Samrat T; Mo, Xiulei et al. (2018) In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nat Commun 9:2732
Zaheer, Mahira; Wang, Changjun; Bian, Fang et al. (2018) Protective role of commensal bacteria in Sjögren Syndrome. J Autoimmun 93:45-56
Lu, Lianghao; Wen, Yefei; Yao, Yuan et al. (2018) Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics 8:2189-2201
Xiong, Wei; Chen, Yuhui; Kang, Xi et al. (2018) Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells. Mol Ther 26:963-975
Zou, Winnie Y; Blutt, Sarah E; Zeng, Xi-Lei et al. (2018) Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep 22:1003-1015
Jones, Kathryn; Versteeg, Leroy; Damania, Ashish et al. (2018) Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease. Infect Immun 86:
Charendoff, Chloé I; Bouchier-Hayes, Lisa (2018) Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp :
Shi, Xiangguo; Kitano, Ayumi; Jiang, Yajian et al. (2018) Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells. Exp Hematol 64:33-44.e5
Chapple, Richard H; Tseng, Yu-Jung; Hu, Tianyuan et al. (2018) Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis. Blood Adv 2:1220-1228

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