Since its inception in 1994, the Center for Aids Research (CFAR) at Case Western Reserve University (CWRU) has been dedicated to coordinating a constantly-expanding spectrum of AIDS-related activities at CWRU and its primary affiliate, University Hospitals of Cleveland (UH). A productive relationship between the CFAR, the CWRU AIDS Clinical Trials Unit (ACTU) and the UH John T. Carey Special Immunology Unit (SIU) spearheads these efforts, ensuring that the two institutions fulfill their mandates as a center of academic excellence and a provider of patient care of the highest quality, respectively. CFAR development continues to benefit from co-operative and interactive ventures forged with additional CWRU centers in priority areas of mutual interest. These include the Cancer Research Center (CRC - AIDS-related malignancies), Skin Disease Research Center (SDRC - HHV-8 and Kaposi's sarcoma), Tuberculosis Research unit (TBRU - HIV/TB interactions) and Center for Medical Mycology (CMM - opportunistic fungal infections). This sustained effort over the last three years as witnessed a two-fold increase in CFAR membership drawn primarily from 12 departments of CWRU and UH), expansion of its present Funded Research Base (FRB) to approximately $13,000,000 in annual direct costs (covering all NIH-funded programs) and recruitment of clinical and basic research faculty. Organization expansion has involved addition of AIDS-Related Malignancies, Clinical Virology/Mycology and Behavioral Research Working Groups to those of International AIDS, Molecular Virology, Mycobacterial Research and Immunology. Finally, an expanded commitment to international AIDS programs has spawned a request to establish an international Clinical Coordination Facility (ICCF) in addition to those providing state-of-the- art technologies for Cytokine Measurement, Biosafety, Molecular Biology and Clinical Research. Collectively, these initiatives attest to successful development of the CWRU CFAR and provide the appropriate platform for its request for renewed funding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
3P30AI036219-10S1
Application #
6781518
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Plaeger, Susan F
Project Start
1994-04-01
Project End
2004-03-31
Budget Start
2002-04-01
Budget End
2004-03-31
Support Year
10
Fiscal Year
2003
Total Cost
$750,000
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
Tomalka, Amanda G; Resto-Garay, Ivelisse; Campbell, Kerry S et al. (2018) In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells. Front Immunol 9:2552
Kalayjian, Robert C; Albert, Jeffrey M; Cremers, Serge et al. (2018) Women have enhanced bone loss associated with phosphaturia and CD4+ cell restoration during initial antiretroviral therapy. AIDS 32:2517-2524
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Mbonye, Uri; Wang, Benlian; Gokulrangan, Giridharan et al. (2018) Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. J Biol Chem 293:10009-10025
Sayin, Ismail; Radtke, Andrea J; Vella, Laura A et al. (2018) Spatial distribution and function of T follicular regulatory cells in human lymph nodes. J Exp Med 215:1531-1542
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Martinez, Leonardo; Shen, Ye; Handel, Andreas et al. (2018) Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda. Lancet Respir Med 6:276-286
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773

Showing the most recent 10 out of 539 publications