Abstract

The Developmental Core is an essential tool used by the Case CFAR to provide support for innovative and successful AIDS-related research activities. The Core has an impressive track record in identifying key focus areas in AIDS research and engaging junior faculty through direct/hands-on mentoring. During the last grant cycle current Asst. Profs. Donald Anthony, David Canaday, David McDonald, Yong Gao, Michael Cho and Scott Sieg were supported by CFAR developmental awards, mentored by senior CFAR faculty, and have now developed strong, independent research programs. These pilot project awards proved absolutely necessary for junior faculty to obtain sufficient preliminary data for an R series NIH grant award. Over the last 5 years the 22 CFAR-supported pilot projects, with a total investment of $712,000, have been leveraged into $11.7 million in NIH and non-NIH grants, or a 16.7-fold return on investment Members of the CFAR Developmental Core scientific review committee take pride in the past success of these junior faculty. To further build on these successes, we have now implemented a formalized mentoring process overseen by the Developmental Core. In addition, in close collaboration with the Administrative Core, Core B works to expand the CFAR membership by providing resources for the recruitment of new faculty and the engagement of faculty who have not previously been involved in HIV/AIDS research in collaborative projects. Finally, Core B interacts with each of the laboratory Cores in the CFAR by providing a scientific review mechanism used to evaluate new capital equipment purchases and project-based core services awards. The Core achieves these objectives through the following mechanisms: ? Junior investigator-initiated pilot project awards and allied mentorship program ? Targeted pilot project awards in areas of high strategic priority ? New faculty recruitment and engagement of senior faculty in HIV/AIDS research ? support for CFAR cores through strategic investments

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI036219-16A1
Application #
7930066
Study Section
Special Emphasis Panel (ZAI1-JBS-A (J1))
Project Start
2010-05-05
Project End
2015-04-30
Budget Start
2010-05-05
Budget End
2011-04-30
Support Year
16
Fiscal Year
2010
Total Cost
$324,946
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Wiredja, Danica D; Tabler, Caroline O; Schlatzer, Daniela M et al. (2018) Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology 15:44
Oliveira, Vitor H F; Perazzo, Joseph D; Josephson, Richard A et al. (2018) Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. J Assoc Nurses AIDS Care 29:775-781
Paparisto, Ermela; Woods, Matthew W; Coleman, Macon D et al. (2018) Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. J Virol 92:
Llewellyn, George N; Alvarez-Carbonell, David; Chateau, Morgan et al. (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24:192-203
Longenecker, Chris T; Sullivan, Claire E; Morrison, Justin et al. (2018) The effects of HIV and smoking on aortic and splenic inflammation. AIDS 32:89-94
Tomas, Myreen E; Mana, Thriveen S C; Wilson, Brigid M et al. (2018) Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice. Antimicrob Agents Chemother 62:
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Sahmoudi, Karima; Abbassi, Hassan; Bouklata, Nada et al. (2018) Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes. BMC Immunol 19:33

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