The major goal of the Penn-CFAR Developmental core is the promotion of AIDS and HIV related research at the University of Pennsylvania, the Children's Hospital of Philadelphia, and the Wistar institute by providing a source of funding for pilot projects. The Developmental Core will support short term (1 year) projects in emerging areas of HIV research, including new research related to the recruitment of new investigators, research by established investigators who are turning their attention to AIDS, and research by AIDS/HIV investigators who are undertaking studies that represent a significant departure from their previous work. For year one of the proposed Penn-CFAR, four projects were chosen for funding: (1) a project by Dr. J. Field on the role of HHV-8 (KSHV) G- protein coupled receptor like molecule (Orf 74) on cell transformation mediated by this virus, (2) a project by Dr. S. Isaacs to develop a vaccinia immunization system with surface expression of the recombinant antigens, (3) a project by Dr. R. Ricciardi to develop a method for screening compounds that inhibit HHV-8 DNA transcription by interrupting the interaction between its polymerase and its processivity factor, and (4) a project by Drs. Watkins and Behrman and a proposal on the sociology of intergenerational transfer of information and resources in an area of high HIV/AIDS incidence. These projects were chosen from 26 submitted for consideration. For years 2-5 of the proposal we will select four projects each year based on (1) scientific excellence, (2) relevance to HIV/AIDS, and (3) programmatic balance in terms of the goals of the Penn-CFAR.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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MacBrayne, Christine E; Marks, Kristen M; Fierer, Daniel S et al. (2018) Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother 73:2112-2119
Veenhuis, Rebecca T; Kwaa, Abena K; Garliss, Caroline C et al. (2018) Long-term remission despite clonal expansion of replication-competent HIV-1 isolates. JCI Insight 3:
Ecker, Christopher; Guo, Lili; Voicu, Stefana et al. (2018) Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep 23:741-755
Schnoll, Robert A; Thompson, Morgan; Serrano, Katrina et al. (2018) Rate of Nicotine Metabolism and Tobacco Use among Persons with HIV: Implications for Treatment and Research. J Acquir Immune Defic Syndr :
Loy, Dorothy E; Rubel, Meagan A; Avitto, Alexa N et al. (2018) Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis. Int J Parasitol 48:531-542
Kendall, Jacob; Anglewicz, Philip (2018) Migration and health at older age in rural Malawi. Glob Public Health 13:1520-1532
Liu, Wei; Krump, Nathan A; MacDonald, Margo et al. (2018) Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts. J Virol 92:
Plenderleith, Lindsey J; Liu, Weimin; MacLean, Oscar A et al. (2018) Adaptive Evolution of RH5 in Ape Plasmodium species of the Laverania Subgenus. MBio 9:
Colón, Krystal; Speicher, David W; Smith, Peter et al. (2018) S100a14 is Increased in Activated Nk Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte-Nk crosstalk. J Acquir Immune Defic Syndr :
Sturgeon, Kathleen M; Hackley, Renata; Fornash, Anna et al. (2018) Strategic recruitment of an ethnically diverse cohort of overweight survivors of breast cancer with lymphedema. Cancer 124:95-104

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