HIV and Aging SWG (SWG_1) The long-term objective of the Harvard University Center for AIDS Research (HU CFAR) HIV and Aging Scientific Working Group (SWG) is to collaborate with the Boston Pepper Older Americans Independence Center (a.k.a. Boston Pepper Center) to 1) build and enable an interactive, community-engaged network to accelerate discovery of mechanisms and biomarkers for decline in immune and physical function in people aging with HIV (PLWH), 2) create a resource infrastructure to support cross-disciplinary proposals related to HIV and aging, and 3) mentor Early Career Investigators (ECI). These goals will be achieved by leveraging unique clinical and basic resources and expertise available to the HU CFAR and the Boston Pepper Center. Since the Boston Pepper Center represents a consortium of investigators focused on aging across multiple institutions, this SWG will catalyze and enable HU CFAR research. The HIV and Aging SWG is responsive to the Office of AIDS Research strategic plan which lists, ?Premature Aging and Frailty? as a high research priority and was identified as a priority research area by our community advisory members.
Aim 1 will identify and engage community members and investigators with research interests at the interface of HIV and aging and convene activities that include an inaugural workshop and a jointly-sponsored (Pepper and CFAR) seminar series to facilitate productive interactions and will sponsor a town-hall style meeting to identify priority research areas and gaps in care among PLWH.
Aim 2 will build an infrastructure to provide access to HU CFAR and Pepper Center expertise and resources to enable collaborative studies. Core service outreach will include physical function assessment (Pepper) and Advanced Lab Technologies Core services (CFAR).
Aim 3 will collaborate with the HU CFAR Developmental and Mentoring Core to develop co-sponsored pilot grants that target ECIs. The RFA will emphasize use of core services from both centers, as well as encourage outreach to investigators from both centers and use of resources in faculty laboratories. We will create an internal grant review process to provide guidance and feedback on ECI-initiated proposals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI060354-16
Application #
9764995
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
16
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Alvi, Raza M; Neilan, Anne M; Tariq, Noor et al. (2018) Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure. J Am Coll Cardiol 72:518-530
Rogers, Brooke G; Mendez, Noelle A; Mimiaga, Matthew J et al. (2018) ""I Wasn't in My Right Mind"": Qualitative Findings on the Impact of Alcohol on Condom Use in Patients Living with HIV/AIDS in Brazil, Thailand, and Zambia (HPTN 063). Int J Behav Med :
Looby, Sara E; Psaros, Christina; Raggio, Greer et al. (2018) Association between HIV status and psychological symptoms in perimenopausal women. Menopause 25:648-656
Bassett, Ingrid V; Xu, Ai; Govere, Sabina et al. (2018) Contraception and PrEP in South African Hair Salons: Owner, Stylist, and Client Views. J Acquir Immune Defic Syndr 79:e78-e81
Shapiro, Adrienne E; Hong, Ting; Govere, Sabina et al. (2018) C-reactive protein as a screening test for HIV-associated pulmonary tuberculosis prior to antiretroviral therapy in South Africa. AIDS 32:1811-1820
Clayton, Kiera L; Collins, David R; Lengieza, Josh et al. (2018) Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol 19:475-486
Ojikutu, Bisola O; Srinivasan, Sumeeta; Bogart, Laura M et al. (2018) Mass incarceration and the impact of prison release on HIV diagnoses in the US South. PLoS One 13:e0198258
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
North, Crystal M; Muyanja, Daniel; Kakuhikire, Bernard et al. (2018) Brief Report: Systemic Inflammation, Immune Activation, and Impaired Lung Function Among People Living With HIV in Rural Uganda. J Acquir Immune Defic Syndr 78:543-548
Bebell, Lisa M; Ngonzi, Joseph; Siedner, Mark J et al. (2018) HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda. AIDS Care 30:943-953

Showing the most recent 10 out of 1030 publications