? Immunology Core (Core C) Importance of Duke CFAR Immunology Core. The overall goal of the Duke CFAR new Immunology Core, formerly the CFAR Flow Cytometry Core, is to provide Duke HIV/AIDS scientists, clinicians, collaborators and trainees access to an innovative, state-of-the-art, and standardized repertoire of immunologic assays that can comprehensively and deeply interrogate the immunologic space in response to HIV-1 infection, vaccination, co-infections and cure strategies. Addressing Gaps in the Field. The CFAR Immunology Core will continue to address gaps in the field. Three key examples of accomplishments to date: 1) Provided implementation and training of standardized neutralization, binding and cellular assays to national and international laboratories such that diverse studies across multiple laboratories can now be directly and rigorously compared for advancing the science to the next phase. 2) Innovation of new assay development and analysis for multiple simultaneous measurements significantly advancing the depth and breadth of immunological information (i.e. global virus panels for neutralization breadth, novel analytical algorithms and training for flow cytometric analyses (such as FLowPET) and multiplex binding breadth assays. 3) Provided proficiency testing for DAIDS-sponsored sites (EQAPOL luminex, ELISpot, Flow-based, viral diversity and neutralizing antibody assays) Thus, the Duke Immunology Core investigators have a strong history together and are uniquely poised to tackle newly emerging gaps in the field of HIV-1 immunology. Relevance of Core to Duke CFAR. The Duke CFAR has five priority areas for innovative research at Duke supported by the science and technology offered by the Immunology Core 1) AIDS-related malignancies and co-infections, 2) HIV and Aging, 3) Latency and Eradication, 4) Mental Health, Substance Abuse, and HIV Outcomes, and 5) HIV Vaccine Design and Evaluation. The Immunology Core's assay platform and commitment to innovation is ideally suited for support of the Duke CFAR priority areas and specific aims, as well as broadly covering the current and emerging needs of the Duke CFAR community of scientists and clinicians. As part of the overall Duke CFAR Aims, the Immunology Core will provide advanced assays and technologies to CFAR investigators, provide support and training for early stage investigators, support NIH initiatives (PAVEG, HVTN, IMPAACT, HPTN, CHAVI-ID, MIG, CURE, EQAPOL, FLowCAP) and collaborative partnerships with other CFARs, and support international in country capacity and scientific training.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
United States
Zip Code
Skalski, Linda M; Towe, Sheri L; Sikkema, Kathleen J et al. (2018) Memory Impairment in HIV-Infected Individuals with Early and Late Initiation of Regular Marijuana Use. AIDS Behav 22:1596-1605
Mitchell, John T; LeGrand, Sara; Hightow-Weidman, Lisa B et al. (2018) Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial. JMIR Mhealth Uhealth 6:e10456
Okeke, Nwora Lance; Alenezi, Fawaz; Bloomfield, Gerald S et al. (2018) Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. J Card Fail 24:496-503
Clement, Meredith E; Seidelman, Jessica; Wu, Jiewei et al. (2018) An educational initiative in response to identified PrEP prescribing needs among PCPs in the Southern U.S. AIDS Care 30:650-655
Price, Alexander M; Messinger, Joshua E; Luftig, Micah A (2018) c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection. J Virol 92:
Knettel, Brandon A; Cichowitz, Cody; Ngocho, James Samwel et al. (2018) Retention in HIV Care During Pregnancy and the Postpartum Period in the Option B+ Era: Systematic Review and Meta-Analysis of Studies in Africa. J Acquir Immune Defic Syndr 77:427-438
Cichowitz, Cody; Watt, Melissa H; Mmbaga, Blandina T (2018) Childbirth experiences of women living with HIV: a neglected event in the prevention of mother-to-child transmission care continuum. AIDS 32:1537-1539
Zhang, Helen L; Rhea, Sarah K; Hurt, Christopher B et al. (2018) HIV Preexposure Prophylaxis Implementation at Local Health Departments: A Statewide Assessment of Activities and Barriers. J Acquir Immune Defic Syndr 77:72-77
Cichowitz, Cody; Mazuguni, Festo; Minja, Linda et al. (2018) Vulnerable at Each Step in the PMTCT Care Cascade: High Loss to Follow Up During Pregnancy and the Postpartum Period in Tanzania. AIDS Behav :
Tabb, Zachary J; Mmbaga, Blandina T; Gandhi, Monica et al. (2018) Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania. AIDS 32:1115-1123

Showing the most recent 10 out of 488 publications