The overall goal of the Imaging Core is to facilitate quantitative and qualitative analysis of obtained by skeletal biology investigators. This will be achieved through the establishment of three resource centers (subcores) which will assist investigators in the following areas: Microscopic Imaging, FACS and Micro-CT Scanning. Each of these services will utilize existing facilities within the University of Connecticut Health Center and will be presented as a separate project. Drs. Mina and Dealy formulated the overall design of the core and will ensure that they operate as planned. However they are not included in the budgets because their anticipated effort is estimated to be small. This is because tow of subcores will be operated by experience faculty members who have already demonstrated the ability to operate a core facility but have not previously focused on problems of interest to the skeletal biologist. Now that they are part of our Center grant, the members of the user group will have unusual access an assistance to incorporate these technologies into their research program. In the case of the muCT core, Dr. Adams is a junior faculty member but with extensive training in biomechanics and an solid base of expertise in CT scanning.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
3P30AR046026-01A1S1
Application #
6503903
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2001-06-01
Project End
2002-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Type
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Jacquin, Claire; Koczon-Jaremko, Boguslawa; Aguila, Hector L et al. (2009) Macrophage migration inhibitory factor inhibits osteoclastogenesis. Bone 45:640-9
Chandhoke, Taranpreet K; Huang, Yu-Feng; Liu, Fei et al. (2008) Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor. Bone 43:101-9
Liu, Fei; Lee, Sun-Kyeong; Adams, Douglas J et al. (2007) CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment. Bone 40:1135-43
Khosla, Sundeep (2007) Re: ""The 3.6 kb DNA fragment from the rat Col1a1 gene promoter drives the expression of genes in both osteoblast and osteoclast lineage cells"" by Boban et al. (Bone 39:1302-1312, 2006). Bone 40:1671-2;author reply 1673-4
Ardeshirpour, Laleh; Dann, Pamela; Adams, Douglas J et al. (2007) Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 148:3875-86
He, Jianing; Rosen, Clifford J; Adams, Douglas J et al. (2006) Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. Bone 38:826-35
Lee, Sun-Kyeong; Kadono, Yuho; Okada, Fumihiko et al. (2006) T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res 21:1704-12
Sher, L B; Harrison, J R; Adams, D J et al. (2006) Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int 79:118-25
Lee, Sun-Kyeong; Kalinowski, Judith F; Jacquin, Claire et al. (2006) Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res 21:695-702
Boban, Ivana; Jacquin, Claire; Prior, Katie et al. (2006) The 3.6 kb DNA fragment from the rat Col1a1 gene promoter drives the expression of genes in both osteoblast and osteoclast lineage cells. Bone 39:1302-12

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