The Integrated Genomics Operation (IGO) Core provides a broad range of services and expertise to Center investigators interested in evaluating gene expression, chromosome structure, and nucleotide sequence on a broad scale. It delivers a comprehensive, rapid, and user-friendly service. IGO enables basic, clinical, and translational research projects across the Center. Through the centralized management of all sequencing activities at MSK, the Core empowers scientists with an array of technological options and the most efficient and cost-effective means of performing high-throughput genomics. Through its production group, the Core supports most functional genomics applications for analysis of DNA and RNA and has the expertise to successfully process challenging samples from all origins (tissue, cell pellets, paraffin curls, blood, serum, etc.). This expertise is particularly important for investigators studying heterogenous tumor types from the MSK tumor bank. If needed, this group can operate in a highly automated environment, from sample reception to sequencing library preparation. The production group is a LEAN operation that minimizes waste and maximizes value at every step. Consequently, turnaround times and prices are competitive with those offered by commercial and other academic entities. The IGO also provides a customized service to investigators wishing to explore new frontiers in applications and technologies. The Informatics group of the Core provides end-to-end software engineering and bioinformatic analysis solutions to the users of its sequencing services. The broad range of services provided by the IGO Core has supported research of 377 investigators in the past year. During the past grant period, the work of the Core has contributed to 882 publications across all programs; 237 of these publications were published in high impact journals.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Okondo, Marian C; Rao, Sahana D; Taabazuing, Cornelius Y et al. (2018) Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Cell Chem Biol 25:262-267.e5
Gutierrez, Alejandro; Kentsis, Alex (2018) Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy. Br J Haematol 180:919-924
Ruff, Emily F; Muretta, Joseph M; Thompson, Andrew R et al. (2018) A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. Elife 7:
Atkins, Katelyn M; Chen, Ming-Hui; Wu, Jing et al. (2018) Low testosterone at first prostate-specific antigen failure and assessment of risk of death in men with unfavorable-risk prostate cancer treated on prospective clinical trials. Cancer 124:1383-1390
Traina, Tiffany A; Miller, Kathy; Yardley, Denise A et al. (2018) Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer. J Clin Oncol 36:884-890
Guo, Jun; Jin, Jie; Oya, Mototsugu et al. (2018) Safety of pazopanib and sunitinib in treatment-naive patients with metastatic renal cell carcinoma: Asian versus non-Asian subgroup analysis of the COMPARZ trial. J Hematol Oncol 11:69
Roselló-Díez, Alberto; Madisen, Linda; Bastide, Sébastien et al. (2018) Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice. PLoS Biol 16:e2005086
Jacobsen, Paul B; DeRosa, Antonio P; Henderson, Tara O et al. (2018) Systematic Review of the Impact of Cancer Survivorship Care Plans on Health Outcomes and Health Care Delivery. J Clin Oncol 36:2088-2100
Haxaire, Coline; Hakobyan, Narine; Pannellini, Tania et al. (2018) Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-? pathway. Blood 132:1064-1074
Parker, Patricia A; Banerjee, Smita C; Matasar, Matthew J et al. (2018) Efficacy of a survivorship-focused consultation versus a time-controlled rehabilitation consultation in patients with lymphoma: A cluster randomized controlled trial. Cancer 124:4567-4576

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