The Microchemistry and Proteomics (MCP) Core provides mass spectrometric sequencing and quantitation of peptides and proteins to support basic, translational, and clinical research programs at MSK. The Core utilizes modern high-resolution mass spectrometry and nanoscale liquid chromatography in conjuction with biochemical processing of samples with the end goal of determining the identity, relative abundance, and presence of post translational modifications from purified components, cell lysates, tissues, and select fluid such as cerebral spinal fluid. Proteins and post translational modification are critical components of complex signaling pathways underlying development, cell growth, differentiation, DNA repair, senescence, immune response to cancer, and response to bioactive therapies. Dissection of these pathways can lead to insights on the underlying molecular mechanisms involved in cancer. The goal of the MCP Core is to be an efficient, user friendly, state-of-the-art facility. Advice is provided by the Core staff to facilitate the design, execution, and analysis of experiments. Over the past year, the Core has supported research from 38 investigators. Over the past grant period, investigators from all 10 programs have been supported, and the Core has contributed to 207 publications.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Owosho, Adepitan A; Zhang, Lei; Rosenblum, Marc K et al. (2018) High sensitivity of FISH analysis in detecting homozygous SMARCB1 deletions in poorly differentiated chordoma: a clinicopathologic and molecular study of nine cases. Genes Chromosomes Cancer 57:89-95
Konishi, Tsuyoshi; Shimada, Yoshifumi; Hsu, Meier et al. (2018) Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome. JAMA Oncol 4:309-315
Escorcia, Freddy E; Steckler, Jeffrey M; Abdel-Atti, Dalya et al. (2018) Tumor-Specific Zr-89 Immuno-PET Imaging in a Human Bladder Cancer Model. Mol Imaging Biol 20:808-815
Yoon, Sam S (2018) The New American Joint Commission on Cancer Staging System for Soft Tissue Sarcomas: Splitting versus Lumping. Ann Surg Oncol 25:1101-1102
Turashvili, Gulisa; Morency, Elizabeth G; Kracun, Mihaela et al. (2018) Morphologic Features of Gastric-type Cervical Adenocarcinoma in Small Surgical and Cytology Specimens. Int J Gynecol Pathol :
Horvat, Natally; Veeraraghavan, Harini; Khan, Monika et al. (2018) MR Imaging of Rectal Cancer: Radiomics Analysis to Assess Treatment Response after Neoadjuvant Therapy. Radiology 287:833-843
Romanoff, Anya; Zabor, Emily C; Stempel, Michelle et al. (2018) A Comparison of Patient-Reported Outcomes After Nipple-Sparing Mastectomy and Conventional Mastectomy with Reconstruction. Ann Surg Oncol 25:2909-2916
Abla, Oussama; Jacobsen, Eric; Picarsic, Jennifer et al. (2018) Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood 131:2877-2890
Soumerai, Tara E; Donoghue, Mark T A; Bandlamudi, Chaitanya et al. (2018) Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer. Clin Cancer Res 24:5939-5947
Hsin, Jing-Ping; Lu, Yuheng; Loeb, Gabriel B et al. (2018) The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types. Nat Immunol 19:1137-1145

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