Protocol Specific Research Support (PSRS) supports the conduct of innovative, high-priority phase I and phase l-ll investigator-initiated trials led by AECC investigators. In order to be eligible for PSRS, the study must be led by AECC investigator or resulted from previous clinical or preclinical studies performed at AECC (with AECOM faculty as co-investigator). A process has been established for designating PSRS, which includes a screen by the CPDMU for eligibility, evaluating the scientific merit of the study (as determined by the PRMC), and assigning priority relative to other AECC investigator-initiated trials. During the last funding period, trials supported by PSRS included protocols evaluating the clinical and immune effects of an HspE7 vaccine in patients with CINIII, the clinical and biologic effects of combining the farnesyltransferase inhibitor tipifarnib with standard chemotherapy in locally advanced breast cancer, and defining the recommended phase II dose, pharmacokinetics, and pharmacodynamics of the epothilone B analog ixabepilone. These studies have led to additional CTEP-sponsored and industry-sponsored phase II and phase III trials evaluating the effects of HsPE7 patients with CINIII, tipifarnib in locally advanced breast cancer, and ixabepilone in patients with advanced breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013330-38
Application #
8113385
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
38
Fiscal Year
2010
Total Cost
$240,820
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
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