Abstract

The research of the MIT Center for Cancer Research (CCR) faculty is focused on elucidating the basic mechanisms of cancer development. It is organized into three distinct programs organized around shared common interests and overlapping long-term goals. These are Program 1: Molecular Genetics and Immunology;Program 2: Genetics and Model Systems;Program 3: Cell Biology. As an NCI-designated basic research center, the CCR is both a physical entity and an organizing body for MIT's cancer research community at large. Of the thirty member laboratories, eleven are located in the Center's home building (E 17/18), the others are located in the Koch Biology Building (4), the Broad Institute (2), Whitehead Institute (7), the Division of Biological Engineering (4), and the Department of Chemistry (1) and the Department of Chemical Engineering (1). The Center functions to facilitate interactions among the member laboratories, foster research collaborations, provide integral core facilities as well as seed funding for cancer research. The Center operates or shares in support of eleven core facilities that provide access for member laboratories to critical research technologies, materials, infrastructure and trained personnel. It also trains a large number of graduate students, postdoctoral fellows, clinical fellows and undergraduate students in basic cancer research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-38
Application #
7668633
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
1997-06-17
Project End
2010-04-30
Budget Start
2009-05-27
Budget End
2010-04-30
Support Year
38
Fiscal Year
2009
Total Cost
$2,844,058
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Tentori, Augusto M; Nagarajan, Maxwell B; Kim, Jae Jung et al. (2018) Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip 18:2410-2424
Parisi, Tiziana; Balsamo, Michele; Gertler, Frank et al. (2018) The Rb tumor suppressor regulates epithelial cell migration and polarity. Mol Carcinog 57:1640-1650
Gam, Jeremy J; Babb, Jonathan; Weiss, Ron (2018) A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity. Nat Commun 9:2430
Chen, Huihui; Cho, Kin-Sang; Vu, T H Khanh et al. (2018) Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun 9:3209
Tam, Brooke E; Hao, Yining; Sikes, Hadley D (2018) An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles. Biotechnol Prog 34:1589-1595
Ramadi, Khalil B; Dagdeviren, Canan; Spencer, Kevin C et al. (2018) Focal, remote-controlled, chronic chemical modulation of brain microstructures. Proc Natl Acad Sci U S A 115:7254-7259
Knouse, Kristin A; Lopez, Kristina E; Bachofner, Marc et al. (2018) Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell 175:200-211.e13
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann et al. (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361:
Fiedler, Eleanor R C; Bhutkar, Arjun; Lawler, Emily et al. (2018) In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1 + BCP-ALL. Blood Adv 2:1229-1242
Clancy-Thompson, Eleanor; Devlin, Christine A; Tyler, Paul M et al. (2018) Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses. Cancer Immunol Res 6:1524-1536

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