The Molecular and Cell Biology (MCB) Support Core provides USC Norris Comprehensive Cancer Center (NCCC) researchers with glassware washing/sterilizing services and shared equipment purchase/ maintenance to support their molecular biology, cell biology, biochemistry, and molecular epidemiology experiments. The MCB Support Core: 1) washes/sterilizes glassware for individual research laboratories, and for the Bioreagent and Cell Culture Core for preparation of sterile culture media;2) prepares doubly deionized, distilled water in large quantities for preparation of reagents for molecular biology, cell biology, and biochemistry experiments;3) supervises/maintains all shared equipment;4) negotiates/administers service contracts for shared, heavily-used, expensive pieces of lab equipment (ECL-Western apparatus, phosphorimagers, ultracentrifuges. X-ray film developers, liquid scintillation counters, shared fluorescent microscopes);5) provides centralized supplies, including carbon dioxide, liquid nitrogen, and dry ice to NCCC labs;6) maintains freezers, refrigerators, balances, and spectrophotometers in individual labs;and 7) assesses needs/makes recommendations for purchase of new shared equipment/services. The Glassware Facilities of the MCB Support Core are located at four sites: Ezralow Tower (1,300 sq. ft., three autoclaves, three glassware washers), Harlyne Norris Research Tower (HNRT, 1,600 sq. ft., four glassware washers, three autoclaves). Cancer Research Laboratories (CRL, 1,000 sq. ft., one autoclave, one glassware washer), and Smith Research Tower at Childrens Hospital Los Angeles (CHLA, 1,000 sq. ft., one autoclave, one glassware washer). This shared resource serves 94 Cancer Center members and their research groups, 500 scientists/technical staff total. The CCSG supports 4.0 FTE glassware technicians;another two are supported by chargebacks. The MCB Support Core is supervised by Dr. Joseph R. Landolph, Associate Professor of Molecular Microbiology and Immunology. Mr. Kent Chang manages the Norris Headquarters and CRL. Dr. Ambrose Jong supervises CHLA facilities. In 2008, we occupied the 103,000 n.s.f. HNRT, housing 40 new Pis. As a result, this MCB Support Core has experienced a very large increased demand for services beginning in 2008 and continuing to the present time.

Public Health Relevance

The MCB Support Core supports research of NCCC members in molecular mechanisms of DNA repair, molecular mechanisms of DNA methylation, and molecular mechanisms of prostate tumor formation, among many research projects. Understanding these processes can lead to novel ways and new drugs to control these processes and thereby to reduce/prevent tumor formation in humans.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Southern California
Los Angeles
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Sebio, A; Stintzing, S; Heinemann, V et al. (2018) A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials. Pharmacogenomics J 18:43-48
Peres, Lauren C; Risch, Harvey; Terry, Kathryn L et al. (2018) Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol 47:460-472
Peddi, Santosh; Pan, Xiaoli; MacKay, John Andrew (2018) Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis. Front Pharmacol 9:1184
Guo, Hao; Lee, Changrim; Shah, Mihir et al. (2018) A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. J Control Release 292:183-195
Zhao, Yi; Wu, Kaijin; Wu, Yongfeng et al. (2018) Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists. Curr Mol Pharmacol 11:113-121
Kahn, Michael (2018) Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators. Prog Mol Biol Transl Sci 153:209-244
Liu, Jie; Liang, Gangning; Siegmund, Kimberly D et al. (2018) Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics 19:369
Park, Sungshim L; Patel, Yesha M; Loo, Lenora W M et al. (2018) Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics 10:110
Schirripa, Marta; Zhang, Wu; Yang, Dongyun et al. (2018) NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients. PLoS One 13:e0193640
McDonnell, Kevin J; Chemler, Joseph A; Bartels, Phillip L et al. (2018) A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster. Nat Chem 10:873-880

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