Functional Genomics and Genome Sequencing Core Shared Resource - Project Summary/Abstract The mission of the Functional Genomics and Genome Sequencing Core is to facilitate cutting-edge genomics research at the Salk Institute by providing: 1) cost-effective and rapid high-throughput sequencing services, 2) expert assistance in experimental design, and 3) the development of novel methods to enable cutting edge sequencing technologies. In addition, the Core prepares sequencing libraries and performs quality control to ensure that high-quality data are extracted from each experimental sample. In the near future, the Core will acquire and implement a single cell sequencing platform. In support of Cancer Center research endeavors at the Salk, the Core specifically aims to provide: 1) access to state-of-the-art instrumentation for next-generation sequencing projects, 2) assistance with experimental design when Salk Cancer Center members are seeking to perform experiments that involve sequencing technologies, 3) novel methods and strategies for implementing cutting-edge sequencing technologies, 4) preparation and quality control of sequencing libraries, and 5) training services for Cancer Center members in library preparation or other methods required for next- generation sequencing projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014195-47
Application #
9853752
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
47
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Lewis Jr, Tommy L; Kwon, Seok-Kyu; Lee, Annie et al. (2018) MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. Nat Commun 9:5008
Eichner, Lillian J; Brun, Sonja N; Herzig, S├ębastien et al. (2018) Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. Cell Metab :
Dravis, Christopher; Chung, Chi-Yeh; Lytle, Nikki K et al. (2018) Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell 34:466-482.e6
Zarrinpar, Amir; Chaix, Amandine; Xu, Zhenjiang Z et al. (2018) Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun 9:2872
Ramaswamy, Suvasini; Tonnu, Nina; Menon, Tushar et al. (2018) Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX. Cell Rep 23:1565-1580
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Sonntag, Tim; Vaughan, Joan M; Montminy, Marc (2018) 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs). FEBS J 285:467-480
Herzig, S├ębastien; Shaw, Reuben J (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19:121-135
Sweeney, Lora B; Bikoff, Jay B; Gabitto, Mariano I et al. (2018) Origin and Segmental Diversity of Spinal Inhibitory Interneurons. Neuron 97:341-355.e3
Hartmann, Phillipp; Hochrath, Katrin; Horvath, Angela et al. (2018) Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology 67:2150-2166

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