During the last five years the Duke Comprehensive Cancer Center has continued to fulfill its mission, maturing as a """"""""matrix-plus"""""""" organization. Five young investigators have been recruited directly into the Section of Cell Growth, Regulation and Oncogenesis. Overall, recruitment throughout the Duke University Medical Center has facilitated growth of the Cancer Center to include 255 members who participate in 12 Programs. The Cancer Center's Programs have been reorganized to reflect more accurately interactions between members, as well s to facilitate more effectively their collaboration. New Programs have been established in Structural Biology, Host Resistance and Leukocyte Biology, Multidisciplinary Clinical Trials and Cancer Prevention, Detection and Control Research. Shared Resources now include 23 facilities that facilitate both laboratory and clinical cancer research. New facilities have been established in protein crystallization, 2-D gel analysis, immunocytochemistry and somatic cell hybridization. Resources have been substantially strengthened in peptide sequencing, molecular graphics, nuclear magnetic resonance, confocal microscopy, in-patient clinical research, bone marrow transplantation and biostatistics. The Cancer Center Isolation Facility has been doubled in size. New construction has been initiated that will provide 40,000 NSF of additional space for Cancer Center investigators in fundamental and bridging sciences. Use of development funds has permitted recruitment into the Section of Cell Growth, Regulation and Oncogenesis, a dramatic expansion of biostatistics, initiation of the Cancer Prevention, Detection and Control Research Program, recruitment in psychosocial investigation, strengthening of Shared Resources, provision of interim funding and the support of pilot projects. Facilitated by the Core Grant, Duke investigators have published greater than 4,500 papers during the last five years that have contributed substantially to the fields of cell regulation, DNA replication, structural biology, viral oncology, leukocyte biology, neurooncology, autologous bone marrow transplantation, gynecologic oncology, multidisciplinary treatment, clinical application of hematopoietic growth factors and cancer screening. Support is requested for Senior Leaders, Program Leaders, Administration, Shared Resources and Development to implement fully the strategic plan for the Duke Comprehensive Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-27
Application #
6137361
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
1976-09-01
Project End
2003-12-31
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
27
Fiscal Year
2000
Total Cost
$5,390,420
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :
Fayanju, Oluwadamilola M; Park, Ko Un; Lucci, Anthony (2018) Molecular Genomic Testing for Breast Cancer: Utility for Surgeons. Ann Surg Oncol 25:512-519
Porter, Laura S; Fish, Laura; Steinhauser, Karen (2018) Themes Addressed by Couples With Advanced Cancer During a Communication Skills Training Intervention. J Pain Symptom Manage 56:252-258
Káradóttir, Ragnhildur T; Kuo, Chay T (2018) Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis. Annu Rev Neurosci 41:139-161
Han, Peng; Liu, Hongliang; Shi, Qiong et al. (2018) Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Mol Carcinog 57:784-793
Xu, Yinghui; Wang, Yanru; Liu, Hongliang et al. (2018) Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. Mol Carcinog 57:22-31
Abdi, Khadar; Kuo, Chay T (2018) Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling. Genes Dev 32:740-741

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