The Biostatistics Shared Resource provides consultation and collaboration for Cancer Institute members in the area of biostatistics. These activities include short and long-range collaboration on statistical design, conduct, and analysis of cancer research projects In the basic and clinical sciences. Activities Include assistance In conceptualizing and developing research projects, collaboration with as yet unfunded investigators in developing new grant applications, protocol development, statistical analyses and reports, preparation of abstracts and manuscripts for publication, the review of all clinical trials as part of service on the Protocol Review Committee, participation In cancer-center pilot projects, and other activities In support of Cancer Institute investigators. Members of this Shared Resource are drawn from a larger pool of statisticians involved In cancer research at Duke, including those working in the Stafisfical Center ofthe Cancer and Leukemia Group B (CALGB). Faculty members In biostatistics are appointed in the Duke Department of Biostafistics and Bioinformafics. There have been over 185 collaborative publicafions in the current grant period (2004 - 2008) and there are currently over 50 active peer-reviewed cancer research grants with partial support for one of the statisticians In the resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-40
Application #
8601857
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
40
Fiscal Year
2014
Total Cost
$210,984
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Vlahovic, Gordana; Meadows, Kellen L; Hatch, Ace J et al. (2018) A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer. Oncologist 23:782-790
Xu, Yinghui; Liu, Hongliang; Liu, Shun et al. (2018) Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer. Int J Cancer 143:2400-2408
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Naqvi, Ibtehaj; Gunaratne, Ruwan; McDade, Jessica E et al. (2018) Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. Mol Ther 26:1020-1031
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Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312
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Bakthavatsalam, Subha; Sleeper, Mark L; Dharani, Azim et al. (2018) Leveraging ?-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. Angew Chem Int Ed Engl 57:12780-12784
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955

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