The Scientific Visualization and Image Analysis (SVIA) Core plays an important role in the UCCRC;its services help to promote collaborations that allow imaging to be used by a number of other programs in the UCRRC. The Core provides three essential services: a high performance computer cluster, a large data storage resource, and software to facilitate the development of databases. In 2007, the computation capabilities of the Core will be upgraded using funds from a recently awarded Shared Instrumentation Grant from the NIH. The new system will have 128 CPUs and 14 TBytes of storage. The Core facilitates the development of databases of patient data by providing a means to collect deidentified patient records, including image data. Since the image is collected in such a way that patient identifiers are removed, researchers do not need to obtain patient consent, and their research is HIPAA compliant. Without this service, collecting patient images would be extremely difficult and timeconsuming. Nearly 4000 patient cases (679 GBytes) were collected in this way. All of these users are conducting research on computer-aided diagnosis, but the Core also supports research on image reconstruction, MR imaging and spectroscopy, electron paramagnetic imaging, and receiver-operating characteristic (ROC) analysis. While most users of the SVIA Core are from the Advanced Imaging Program, the use of the Core facilitates collaborations with members of other Programs, such as the Cancer Risk and Prevention Program. The SVIA Core's future plans include supporting the expansion of the Advanced Imaging Program to promote collaboration between experts in medical imaging and members in other programs. One way this will be done is to create a list of software developed by members of the Advanced Imaging Program that is available to UCCRC members. The goal is to have non-imaging experts team up with members of the Advanced Imaging Program to apply or modify existing software to solve or help solve problems in the basic biological sciences or in clinical medicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-34
Application #
7843301
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
34
Fiscal Year
2009
Total Cost
$94,664
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Karrison, Theodore; Kocherginsky, Masha (2018) Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials? Clin Trials 15:178-188
An, Ningfei; Khan, Saira; Imgruet, Molly K et al. (2018) Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood 131:2682-2697
Trujillo, Jonathan A; Sweis, Randy F; Bao, Riyue et al. (2018) T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Cancer Immunol Res 6:990-1000
Zeng, Zongyue; Huang, Bo; Huang, Shifeng et al. (2018) The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs. Genes Dis 5:62-74
Lee, Ji-Hye; Park, Beom Seok; Han, Kang R et al. (2018) Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol 9:1466
Cheng, Jason X; Chen, Li; Li, Yuan et al. (2018) RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun 9:1163
Johnson, Marianna B; Hoffmann, Joscelyn N; You, Hannah M et al. (2018) Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia 23:59-73
Sweis, Randy F; Zha, Yuanyuan; Pass, Lomax et al. (2018) Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer. J Immunother Cancer 6:24
Kathayat, Rahul S; Cao, Yang; Elvira, Pablo D et al. (2018) Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9:334
Liu, Jun; Eckert, Mark A; Harada, Bryan T et al. (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074-1083

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