The Cell Signaling and Gene Regulation Program (Program 1) brings together a group of basic and translational investigators dedicated to the study of cancer through research in cell signaling, molecular biology, systems biology, developmental biology, and chemistry/drug discovery. The program has 46 members from 13 Departments, and members have a total of $16,459,487 in peer-reviewed funding with $5,012,818 from the NCI. Program members have been highly-productive, with 599 peer-reviewed publications, including 7% that were intraprogrammatic, and 15% interprogrammatic publications. The scientific goals of the Cell Signaling and Gene Regulation Program are to determine the basic cell signaling and gene expression mechanisms that underlie malignancy. To this end, our membership's research focuses on determining the mechanisms whereby genes, and the proteins they encode, function in both normal and cancerous conditions. In the previous funding period, Program 1 has increased its membership size from 25 to 46 members, reflecting a major recruitment of physician-scientists studying basic mechanisms of disease, as well as systems biologists. In addition, the UCCRC's outreach to physical scientists interested in collaborative interdisciplinary cancer research has also enriched the membership of Program 1. Overall, the research objectives of our scientists can be divided into the following five themes: (1) to elucidate the molecular mechanisms of tissue-specific and cell type-specific gene expression;(2) to elucidate the cellular mechanisms underlying cell growth/division and cell survival/death;(3) to understand the multi-faceted mechanisms leading to cancer metastases;(4) to use large-scale, high-throughput systems biology approaches and genetic evolutionary approaches to understand cancer biology;and (5) to discover novel developmental pathways relevant to cancer cell signaling. Although our members'interests are varied, many common themes have emerged. Moreover, in the current funding period, our membership has developed numerous collaborations with clinician scientists both within Program 1 and interprogramatically, reflecting the increasingly cross-disciplinary and translational nature of our research program. Through pilot funding, quarterly membership meetings, a seminar series, an annual retreat, and a strong basic science training program in cancer biology, Program 1 is poised to continue its successful in-depth and basic research focus on cancer biology, while nurturing collaborative science that will enhance clinical care of patients at risk or with cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Special Emphasis Panel (ZCA1)
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University of Chicago
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Sample, Ashley; He, Yu-Ying (2018) Mechanisms and prevention of UV-induced melanoma. Photodermatol Photoimmunol Photomed 34:13-24
Jeong, Choongwon; Witonsky, David B; Basnyat, Buddha et al. (2018) Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal. PLoS Genet 14:e1007650
Wang, Xin; Wu, Xingye; Zhang, Zhonglin et al. (2018) Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep 8:17914
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Karrison, Theodore; Kocherginsky, Masha (2018) Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials? Clin Trials 15:178-188
An, Ningfei; Khan, Saira; Imgruet, Molly K et al. (2018) Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood 131:2682-2697
Trujillo, Jonathan A; Sweis, Randy F; Bao, Riyue et al. (2018) T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Cancer Immunol Res 6:990-1000
Zeng, Zongyue; Huang, Bo; Huang, Shifeng et al. (2018) The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs. Genes Dis 5:62-74
Lee, Ji-Hye; Park, Beom Seok; Han, Kang R et al. (2018) Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol 9:1466
Cheng, Jason X; Chen, Li; Li, Yuan et al. (2018) RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun 9:1163

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