BIOSTATISTICS & COMPUTATIONAL BIOLOGY (BCB) Quantitative and data sciences have penetrated nearly all aspects of biomedical research. With that comes challenges and opportunities to develop the methods needed to make valid and efficient use of these data for inference on human health and medicine. The Biostatistics & Computational Biology (BCB) Program provides the intellectual environment for advancing these efforts. Our research program portfolio spans a broad range of activities from statistical methods development to biological research that uses experimental studies in conjunction with computational methods. Our statistical research emphasizes analytic approaches to genome-scale data sets, molecular diagnostics, development and applications of objective measures of lifestyle and environmental exposures, and methods for clinical trials. Highlights include breakthroughs in prostate and colorectal cancer screening analysis, new methods for design and analysis of therapeutic trials, and the development of new statistical approaches for precision medicine and biomarker discovery. Biological research is concentrated on cancer-relevant aspects of quantitative immune profiling, infectious disease/microbiome, and basic molecular biology. BCB members have identified new therapeutic avenues for treatment of leukemias and novel predictive markers of immunotherapy response. Our research is characterized by a productive interplay between applied work and methods development.
Our specific aims are to develop rigorous statistical and mathematical methods relevant to predictive and personalized medicine; to develop and use experimental, technological, and companion computational or mathematical methods to gain understanding of the natural history of cancer, and to develop and disseminate statistical and computational methods in cancer research. A substantial portion of our research is in areas of emphasis such as high-dimensional data analysis, immune profiling, mobile device data, and machine learning that were not a major focus 5 years ago. The ongoing growth and development of high-throughput technologies for acquiring biological data provides great opportunities and challenges for statisticians and computational researchers to make impactful contributions in cancer research. BCB members are well-positioned to capitalize on these exciting opportunities: we have a wide range of quantitative methodological training augmented by cancer-relevant domain knowledge; we have outstanding collaborations; we are strongly committed to translating our methods research into new diagnostic tools and therapies; and we are attentive to emerging opportunities in biomedical data science.
|Syrjala, Karen L; Yi, Jean C; Artherholt, Samantha B et al. (2018) An online randomized controlled trial, with or without problem-solving treatment, for long-term cancer survivors after hematopoietic cell transplantation. J Cancer Surviv 12:560-570|
|Hempstead, Bridgette; Green, Cynthia; Briant, Katherine J et al. (2018) Community Empowerment Partners (CEPs): A Breast Health Education Program for African-American Women. J Community Health 43:833-841|
|OhAinle, Molly; Helms, Louisa; Vermeire, Jolien et al. (2018) A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. Elife 7:|
|Liu, Yanyan; Xiong, Sican; Sun, Wei et al. (2018) Joint Analysis of Strain and Parent-of-Origin Effects for Recombinant Inbred Intercrosses Generated from Multiparent Populations with the Collaborative Cross as an Example. G3 (Bethesda) 8:599-605|
|Liu, Yang; He, Qianchan; Sun, Wei (2018) Association analysis using somatic mutations. PLoS Genet 14:e1007746|
|Glaser, Adam K; Chen, Ye; Yin, Chengbo et al. (2018) Multidirectional digital scanned light-sheet microscopy enables uniform fluorescence excitation and contrast-enhanced imaging. Sci Rep 8:13878|
|Du, Jing; Flynn, Ryan; Paz, Katelyn et al. (2018) Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients. Blood 131:1743-1754|
|Mora-Pinzon, Maria C; Trentham-Dietz, Amy; Gangnon, Ronald E et al. (2018) Urinary Magnesium and Other Elements in Relation to Mammographic Breast Density, a Measure of Breast Cancer Risk. Nutr Cancer 70:441-446|
|Shirts, Brian H; Konnick, Eric Q; Upham, Sarah et al. (2018) Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes. Am J Hum Genet 103:19-29|
|Kuzma, Jessica N; Hagman, Derek K; Cromer, Gail et al. (2018) Intra-individual variation in markers of intestinal permeability and adipose tissue inflammation in healthy normal weight to obese adults. Cancer Epidemiol Biomarkers Prev :|
Showing the most recent 10 out of 1267 publications