Shared instrumentation represents a institute-wide resource set up with modular locations to serve each of the CCSG Programs. Modular resources are housed in the Grace Cancer Drug Center (Therapeutics), Cell and Virus (Cancer Genetics and Mouse Molecular Genetics), and the Cancer Cell Center (Immunology). Mot of the equipment included within this resource is represented by those items common to most types of biomedical research. There are several objectives in maintaining shared instrumentation. Centralized support of this resource ensures continuous access to equipment commonly used by a variety of investigators conducting peer reviewed research and to allow access to those investigators applying for such support. Centralized equipment ensures maximum utilization and therefore cost efficiency of research dollars. Equipment included in the shared instrumentation resource is generally lumped together for service contract agreements. The inclusion of multiple pieces of equipment on the same service contract allow for discounted rates, stability of service contract agreements and minimization of disrupts due to equipment breakdown. Shared instrumentation also increases the availability of high-end equipment (e.g., ultracentrifuges, densitometers, imaging equipment) for which support by traditional individual investigator type funding (e.g., RO1 type support) is difficult to obtain. The shared instrumentation resource, in addition to allowing investigators to have access to a reliable facility for conducting a multitude of essential but conventional type studies, but also can allow investigators to take advantage of newly developed technology that requires equipment not generally supported by individual investigator awards.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016056-26
Application #
6452245
Study Section
Project Start
2001-05-07
Project End
2003-04-30
Budget Start
Budget End
Support Year
26
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Eng, Diana G; Kaverina, Natalya V; Schneider, Remington R S et al. (2018) Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing. Kidney Int 93:1240-1246
Ling, Xiang; Wu, Wenjie; Fan, Chuandong et al. (2018) An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. J Exp Clin Cancer Res 37:240
Chung, Sejin; Vail, Paris J; Witkiewicz, Agnieszka K et al. (2018) Coordinately targeting cell cycle checkpoint functions in integrated models of pancreatic cancer. Clin Cancer Res :
Mohammadpour, Hemn; O'Neil, Rachel; Qiu, Jingxin et al. (2018) Blockade of Host ?2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs. J Immunol 200:2479-2488
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Sandlesh, Poorva; Juang, Thierry; Safina, Alfiya et al. (2018) Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. PLoS One 13:e0199785
Zhang, Dingxiao; Zhao, Shuhong; Li, Xinyun et al. (2018) Prostate Luminal Progenitor Cells in Development and Cancer. Trends Cancer 4:769-783
Hong, Chi-Chen; Sucheston-Campbell, Lara E; Liu, Song et al. (2018) Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 27:321-330
Damayanti, Nur P; Budka, Justin A; Khella, Heba W Z et al. (2018) Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clin Cancer Res 24:5977-5989
Mayor, Paul; Starbuck, Kristen; Zsiros, Emese (2018) Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies. Gynecol Oncol 150:361-369

Showing the most recent 10 out of 1555 publications