The major goals of the Small Animal Imaging Core are to establish the needed infrastructure and develop image analysis tools for providing services to members of the UNC Lineberger Comprehensive Cancer Center. The Core will provide two main categories of services, including image acquisition and image analysis. The imaging modalities for the former service include magnetic resonance imaging/spectroscopy (MRI/MRS), single photon emission tomography (SPECT), optical imaging and computed tomography (CT). In particular, our research team has devised the SPECT and the first reported CT using a field emission carbon nanotube x-ray source. The ability to devise the imaging devices is likely to offer substantial flexibility to further improve the image quality in the near future. The latter service will provide image analysis tools such as lesion segmentation and co-registration for images acquired from the same animal but different modalities and/or different animals so that a group analysis can be conducted. The SAI core is led by Dr. Weili Lin who has extensive experience in MR imaging. The image analysis component will be led by Dr. Steve Aylward, who likewise has extensive experieince and funded research in image analysis. The Core adds value to the Center by offering non-invasive approaches to assess in vivo conditions and allow longitudinal studies, most likely substantially reducing the number of animals needed. In addition, the availability of multiple imaging modalities and the image analysis tools will provide powerful tools for the study of cancer mechanisms non-invasively.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-34
Application #
7751861
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
34
Fiscal Year
2009
Total Cost
$175,843
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Smith, Jennifer S; Des Marais, Andrea C; Deal, Allison M et al. (2018) Mailed Human Papillomavirus Self-Collection With Papanicolaou Test Referral for Infrequently Screened Women in the United States. Sex Transm Dis 45:42-48
Morris, Michael J; Rumble, R Bryan; Basch, Ethan et al. (2018) Optimizing Anticancer Therapy in Metastatic Non-Castrate Prostate Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 36:1521-1539
Hisada, Yohei; Thålin, Charlotte; Lundström, Staffan et al. (2018) Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients. Thromb Res 165:1-5
Westmoreland, Katherine D; El-Mallawany, Nader K; Kazembe, Peter et al. (2018) Dissecting heterogeneous outcomes for paediatric Burkitt lymphoma in Malawi after anthracycline-based treatment. Br J Haematol 181:853-854
Kulis, Michael; Yue, Xiaohong; Guo, Rishu et al. (2018) High- and low-dose oral immunotherapy similarly suppress pro-allergic cytokines and basophil activation in young children. Clin Exp Allergy :
Malta, Tathiane M; Sokolov, Artem; Gentles, Andrew J et al. (2018) Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. Cell 173:338-354.e15
Lund, Jennifer L; Sanoff, Hanna K; Peacock Hinton, Sharon et al. (2018) Potential Medication-Related Problems in Older Breast, Colon, and Lung Cancer Patients in the United States. Cancer Epidemiol Biomarkers Prev 27:41-49
Wu, Shih-Ying; Fix, Samantha M; Arena, Christopher B et al. (2018) Focused ultrasound-facilitated brain drug delivery using optimized nanodroplets: vaporization efficiency dictates large molecular delivery. Phys Med Biol 63:035002
Juliano, Rudolph L; Wang, Ling; Tavares, Francis et al. (2018) Structure-activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides. Nucleic Acids Res 46:1601-1613
El-Mallawany, Nader Kim; Kamiyango, William; Villiera, Jimmy et al. (2018) Proposal of a Risk-Stratification Platform to Address Distinct Clinical Features of Pediatric Kaposi Sarcoma in Lilongwe, Malawi. J Glob Oncol :1-7

Showing the most recent 10 out of 1525 publications