Tissue Procurement and Biospecimens Core Facility The major objective of the Tissue Procurement and Biospecimens Core Facility is to support and enhance cancer-related translational, clinical, population and basic science research. This is achieved by providing UNC Lineberger Comprehensive Cancer Center members with a centralized, coordinated, quality controlled, quality-assured facility for the procurement, processing, storage, and distribution of biologic specimens. Such specimens include normal and malignant tissue, blood, buccal samples, cell lysates, saliva, urine and adipose, collected from human subjects with and without cancer. The facility procures biologic specimens for utilizing its own IRB-approved protocols. The facility now serves over 50 IRB approved protocols. It will begin to serve the UNC Health Registry Cancer Survivorship Cohort protocol that incorporates a global consent process developed to support the enrollment into the planned 10,000 patient Cancer Survivorship Cohort with well-characterized, clinically annotated biologic specimens. The facility provides laboratory support and storage capabilities for both clinical and epidemiologic cancer research studies. For investigator driven studies, the core accommodates investigator specific needs and applications, including planning and performing experiments to optimize specimen handling. In addition, the facility supports many pilot studies and institutionally supported studies to obtain preliminary data for subsequent peer-reviewed grants, especially for newly recruited clinical faculty. During 2009, the facility collected tissue samples from 1094 patients and distributed 674 samples to LCCC members. A major service of the facility is DNA extraction, quantitation, normalization, quality analysis and aliquoting. Additionally, the core coordinates and integrates activities with several other cores, including the Translational Core, the Genomics Core, the Proteomics Core, the Next Generation Sequencing and Genotyping Core, the Biostatistics and Data Management Core, and the Bioinformatics Core. All aspects of sample processing are tracked, using a unique identifier, from arrival in the lab through processing, storage, and disbursement. Distribution of biologic specimens and corresponding data is facilitated by the Lineberger Data-Biologies Governance/Sharing Committees and guidelines. We request $297,439 in CCSG funds, representing 20% of the core's operating costs for 2010. Over 90% of the tissues use was by LCCC members. Members accounted for 79 % of blood and other biospecimen use.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-35
Application #
8340347
Study Section
Subcommittee G - Education (NCI)
Project Start
2011-05-23
Project End
2015-11-30
Budget Start
2011-05-23
Budget End
2011-11-30
Support Year
35
Fiscal Year
2011
Total Cost
$297,051
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Ubil, Eric; Caskey, Laura; Holtzhausen, Alisha et al. (2018) Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest 128:2356-2369
Hamad, Ahmad; Iweala, Onyinye I; Henderson, Cory et al. (2018) Recurrent anaphylaxis during cardiac catheterization due to ethylene oxide. J Allergy Clin Immunol Pract 6:2148-2150
Mayer, Deborah K; Landucci, Gina; Awoyinka, Lola et al. (2018) SurvivorCHESS to increase physical activity in colon cancer survivors: can we get them moving? J Cancer Surviv 12:82-94
Huo, Dezheng; Perou, Charles M; Olopade, Olufunmilayo I (2018) Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply. JAMA Oncol 4:883-884
Howe, Chanelle J; Robinson, Whitney R (2018) Survival-related Selection Bias in Studies of Racial Health Disparities: The Importance of the Target Population and Study Design. Epidemiology 29:521-524
Byrne, James D; Yeh, Jen Jen; DeSimone, Joseph M (2018) Use of iontophoresis for the treatment of cancer. J Control Release 284:144-151
Wilkin, Timothy J; Chen, Huichao; Cespedes, Michelle S et al. (2018) A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298. Clin Infect Dis 67:1339-1346
Siegel, Marni B; He, Xiaping; Hoadley, Katherine A et al. (2018) Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest 128:1371-1383
Chen, Xiu-Fei; Tian, Meng-Xin; Sun, Ren-Qiang et al. (2018) SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep 19:
Horne, Hisani N; Oh, Hannah; Sherman, Mark E et al. (2018) E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. Sci Rep 8:6574

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