ASTRACT - Biostatistics (BIOS) Shared Resource The principal objective of the Biostatistics (BIOS) SR Facility is to provide the highest level possible of quality statistical consultation services to UNC?s Lineberger Comprehensive Cancer Center (LCCC) members. BIOS provides Cancer Center members support for the design, conduct, analysis, and generation of manuscripts for their research. BIOS adds value to the LCCC through close collaboration with multiple center members providing invaluable expertise for their research. Areas of expertise in support of future use by LCCC members include clinical trials and other forms of clinical research, computational biology, genomics, genetics, cancer epidemiology, quality of life, outcomes, and other forms of population sciences research. BIOS also provides service and leadership on complex and multi-component applications such as SPORE and Program Project grants and investigator initiated trials. BIOS SR?s service and leadership on the Protocol Review, Data and Safety Monitoring Committees greatly benefits LCCC member research efforts. Highlights of statistical science that directly benefits LCCC member-related research include: a novel approach to unsupervised screening of genetic loci across RNA-seq cohorts, sampling helps understand organizational correlates of adolescent immunization, clinical trialists benefit from advances in statistical approaches in oncology drug development and efficient designs for phase II oncology trials with ordinal outcome, and statistical methods for high-throughput sequencing technology in DAE-seq (DNA after enrichment sequencing) data analysis improves results. In 2014, 10,775 hours of consultative and other biostatical services were utilized. Since 2010, the BIOS user group grew and diversified, particularly those members needing assistance with statistical methods for basic science/genomic, clinical/translational, and population sciences research. Requested CCSG funding is $288,650, representing 30% of projected operating costs. The BIOS SR plans to expand statistical areas of expertise to meet the expected and growing needs of Cancer Center members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-44
Application #
9834856
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
44
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Yang, Yanyan; Adebali, Ogun; Wu, Gang et al. (2018) Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. Proc Natl Acad Sci U S A 115:E4777-E4785
Kudlacek, Stephan T; Premkumar, Lakshmanane; Metz, Stefan W et al. (2018) Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins. J Biol Chem 293:8922-8933
Woappi, Yvon; Hosseinipour, Maria; Creek, Kim E et al. (2018) Stem Cell Properties of Normal Human Keratinocytes Determine Transformation Responses to Human Papillomavirus 16 DNA. J Virol 92:
Collins, Kyla A L; Stuhlmiller, Timothy J; Zawistowski, Jon S et al. (2018) Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer. Oncotarget 9:15480-15497
Corcoran, Ryan B; André, Thierry; Atreya, Chloe E et al. (2018) Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer. Cancer Discov 8:428-443
Brewer, Noel T; Parada Jr, Humberto; Hall, Marissa G et al. (2018) Understanding Why Pictorial Cigarette Pack Warnings Increase Quit Attempts. Ann Behav Med :
Hall, Marissa G; Sheeran, Paschal; Noar, Seth M et al. (2018) Negative affect, message reactance and perceived risk: how do pictorial cigarette pack warnings change quit intentions? Tob Control 27:e136-e142
Mi, Yu; Smith, Christof C; Yang, Feifei et al. (2018) A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy. Adv Mater 30:e1706098
Yumerefendi, Hayretin; Wang, Hui; Dickinson, Daniel J et al. (2018) Light-Dependent Cytoplasmic Recruitment Enhances the Dynamic Range of a Nuclear Import Photoswitch. Chembiochem 19:1319-1325
Dougherty, Michael K; Brenner, Alison T; Crockett, Seth D et al. (2018) Evaluation of Interventions Intended to Increase Colorectal Cancer Screening Rates in the United States: A Systematic Review and Meta-analysis. JAMA Intern Med 178:1645-1658

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