-Translational Pathology (TP) Shared Resource The Translational Pathology (TP) is a valuable resource for all aspects of experimental pathology for Cancer Center members conducting basic, translational, and clinical cancer research. The TP combines two successful LCCC cores under joint management, the Animal Histopathology Core, serving pre-clinical researchers utilizing animal models, and the Translational Pathology Laboratory, serving clinical researchers utilizing archival patient tissues from the TPF and UNC Hospitals. The TP adds value to the Cancer Center by offering its investigators competitive pricing on a wide range of histopathology services at an on -campus location with convenient access to expert pathology consultation. The Core is co-directed by Faculty Directors Ryan Miller, MD, PhD, and Stephanie Montgomery, DVM, PhD, who together have expertise in human and animal diseases, along with the guidance and experience of Facility Directors Nana Nikolaishvili Feinberg, PhD, and Dawud Hilliard. Dr. Bernand Weismann has been leading the Animal Histopathology component on an interim basis since Dr. Roger?s departure. The Core staff provides a wide range of histology services, including tissue embedding and sectioning (frozen and paraffin), routine and special histologic stains, consultation on study design and tissue collection, tissue microarray (TMA) design and construction, single and multiplex immunohistochemistry, RNA in situ hybridization (ISH), and advanced digital pathology services. During the last grant cycle, the Core has grown with added services and personnel, driven by increased NIH funding awarded to UNC investigators, expanded on-campus animal housing facilities, and the maturation of large on-campus initiatives, including the Collaborative Cross and Mouse Phase 1 Unit. During the next funding period, the TP will expand available services and technologies to meet the demands of Cancer Center investigators, including advancing available animal immunohistochemistry and immunofluorescence reagents, developing FISH assay using commercially available PNA (peptide nucleic acid) and LSI/CEP probes, and acquiring a new state-of ?the-art fluorescent scanner with higher speed, capacity, and magnification for scanning of IF and FISH slides. Accordingly, we request an increased budget of $216,836 representing 5% of the total TP budget to promote expanded utilization and capabilities.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Lim, Joseph K; Liapakis, Ann Marie; Shiffman, Mitchell L et al. (2018) Safety and Effectiveness of Ledipasvir and Sofosbuvir, With or Without Ribavirin, in Treatment-Experienced Patients With Genotype 1 Hepatitis C Virus Infection and Cirrhosis. Clin Gastroenterol Hepatol 16:1811-1819.e4
Wang, Gary P; Terrault, Norah; Reeves, Jacqueline D et al. (2018) Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection. Sci Rep 8:3199
Phillips, Bonnie; Van Rompay, Koen K A; Rodriguez-Nieves, Jennifer et al. (2018) Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques. J Virol 92:
Lianga, Noel; Doré, Carole; Kennedy, Erin K et al. (2018) Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset. PLoS Genet 14:e1007029
Allott, Emma H; Geradts, Joseph; Cohen, Stephanie M et al. (2018) Frequency of breast cancer subtypes among African American women in the AMBER consortium. Breast Cancer Res 20:12
Dhungel, Bal Mukunda; Montgomery, Nathan D; Painschab, Matthew S et al. (2018) 'Discovering' primary effusion lymphoma in Malawi. AIDS 32:2264-2266
Cameron, Jennifer E; Rositch, Anne F; Vielot, Nadja A et al. (2018) Epstein-Barr Virus, High-Risk Human Papillomavirus and Abnormal Cervical Cytology in a Prospective Cohort of African Female Sex Workers. Sex Transm Dis 45:666-672
Stanley, Christopher C; van der Gronde, Toon; Westmoreland, Kate D et al. (2018) Risk factors and reasons for treatment abandonment among children with lymphoma in Malawi. Support Care Cancer 26:967-973
Dronamraju, Raghuvar; Jha, Deepak Kumar; Eser, Umut et al. (2018) Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Res 46:1331-1344
Koehler, Jennifer W; Miller, Andrew D; Miller, C Ryan et al. (2018) A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma. J Neuropathol Exp Neurol 77:1039-1054

Showing the most recent 10 out of 1525 publications