Center for Biospecimen Research & Development (CBRD) The Center for Biospecimen Research and Development (CBRD) was launched in 2015 and has replaced the BioRepository Center (BRC) shared resource presented at the last CCSG review on 2012. Under the direction of Andre Moreira, MD, PhD, Director of Surgical Pathology at NYU Langone Health (NYULH) and a recognized expert in lung pathology and biospecimen research, CBRD was created to support the increased demand across the NYULH research enterprise for standardized human biospecimens. CBRD focuses on improving the accessibility of human biospecimen resources to investigators and increasing institution-wide banking efforts and capacity. CBRD has implemented a campus-wide universal consent and policy for human biospecimen collection and storage to ensure regulatory compliance. CBRD provides well- annotated, high quality biospecimens that foster impactful translational research, thus guaranteeing the clinical relevance of basic findings. CBRD also supports the rapidly expanding portfolio of Perlmutter Cancer Center (PCC) investigator initiated clinical trials by facilitating acquisition, processing and distribution of biospecimens from enrolled patients. All of the samples collected are linked to clinical information obtained in our electronic medical record, EPIC.
The Specific Aims of CBRD are:
Aim 1) To maintain and expand a prospective Biospecimen Repository of PCC patient samples, as well as maintain and expand its linked clinicopathological information;
Aim 2) To process biospecimens, including by carrying out nucleic acid extraction and provide specialized Pathology support;
Aim 3) To stimulate collaborations involving the distribution of human biospecimens;
and Aim 4) To apply high quality control that meets national and international standards, as well as governance over biospecimen utilization.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016087-38
Application #
9633408
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
2024-02-29
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
38
Fiscal Year
2019
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Wang, Shiyang; Liechty, Benjamin; Patel, Seema et al. (2018) Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. J Neurooncol 138:183-190
Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle et al. (2018) H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest 128:233-247
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Ge, Wenzhen; Clendenen, Tess V; Afanasyeva, Yelena et al. (2018) Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts. Int J Cancer 142:2215-2226
Ruggles, Kelly V; Wang, Jincheng; Volkova, Angelina et al. (2018) Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village. mSphere 3:
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Gupta, Ankit; Xu, Jing; Lee, Shirley et al. (2018) Facile target validation in an animal model with intracellularly expressed monobodies. Nat Chem Biol 14:895-900
Marié, Isabelle J; Chang, Hao-Ming; Levy, David E (2018) HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies. J Exp Med 215:3194-3212
Evensen, Nikki A; Madhusoodhan, P Pallavi; Meyer, Julia et al. (2018) MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia. Haematologica 103:830-839
Lee, Hyun-Wook; Park, Sung-Hyun; Weng, Mao-Wen et al. (2018) E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A 115:E1560-E1569

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