The mission of the Tumor Immunology Program (TIM) is to unite investigators who share a commitment to work collaboratively to advance our understanding of the relationship between cancer and the immune system, and develop innovative and effective immune-based therapeutics. The overarching goal of TIM is to elucidate the mechanisms of interactions between the immune system and cancer cells, providing the rationale for the design of more effective approaches to cancer treatment. TIM investigators operate at three levels: (i) Basic research investigating the cellular and molecular mechanisms that regulate the immune response to cancer, (ii) Translational research that helps transition basic findings into therapies and test these therapies in appropriate preclinical models, and (iii) Clinical research that designs and executes clinical trials testing novel immune- based cancer vaccines or innovative immunotherapies. Research is organized around 3 complementary thematic aims:
Aim 1 : To discover basic mechanisms regulating anti-tumor immunity and its evasion, Aim 2: To elucidate the effect of the mcirobiome on anti-tumor immunity and response to therapy, Aim 3: To develop strategies to enhance the efficacy of immunotherapy.TIM is composed of 30 members, drawn from 12 departments in NYU School of Medicine and from NYU College of Dentistry. Members are currently PIs on 80 funded cancer-related projects, delivering $11.7M in annual direct costs ($2.5M NCI). During the funding period, TIM members were responsible for paradigm-shifting basic research findings in cancer immunology, and also conducted several practice-changing randomized clinical trials. TIM research led to the design of several new immune-based therapeutics, and TIM physician members accrued 689 patients to immunotherapy studies over the past 6 years. Of note, PCC is also the only institution in New York to open immuno-oncology trials at a public safety net hospital. Members also lead many innovative early phase clinical trials that emanated directly from basic science research in our laboratories. Since 2012, program members published 443 cancer-related papers, many in the leading venues in biomedical science (~25% were in journals with IF >20). The program is highly interactive, as exemplified by our 23 active multi-PI grants and collaborative publications (12% intra-programmatic/23% inter-programmatic/29% inter-NCI-CC). TIM members also filed 187 invention disclosures, signed 11 license agreements, and founded 3 immunotherapy-based start-up companies. TIM derives great benefit from being an integral part of PCC. In the current cycle, 8 TIM members received pilot funding from PCC totaling $190,000, which seeded numerous productive collaborations. These, in turn, led to novel scientific discoveries, development of innovative experimental therapeutics, successful clinical trial implementation, and NIH and foundation funding totaling more than $2.4 million dollars for a >1100% return on investment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-39
Application #
9867648
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-03-01
Budget End
2021-02-28
Support Year
39
Fiscal Year
2020
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Litwinoff, Evelyn M S; Gold, Merav Y; Singh, Karan et al. (2018) Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet. Obes Res Clin Pract 12:174-186
Snetkova, Valentina; Skok, Jane A (2018) Enhancer talk. Epigenomics 10:483-498
Fan, Xiaozhou; Alekseyenko, Alexander V; Wu, Jing et al. (2018) Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut 67:120-127
Gregory, Ann C; Sullivan, Matthew B; Segal, Leopoldo N et al. (2018) Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome. Respir Res 19:174
Lee, Chul-Hwan; Holder, Marlene; Grau, Daniel et al. (2018) Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2. Mol Cell 70:435-448.e5
Bertrand, Anne; Baron, Maria; Hoang, Dung M et al. (2018) In Vivo Evaluation of Neuronal Transport in Murine Models of Neurodegeneration Using Manganese-Enhanced MRI. Methods Mol Biol 1779:527-541
Taylor, Martin S; Altukhov, Ilya; Molloy, Kelly R et al. (2018) Dissection of affinity captured LINE-1 macromolecular complexes. Elife 7:
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Jung, Seungyoun; Allen, Naomi; Arslan, Alan A et al. (2018) Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts. Int J Cancer 142:262-270
Gong, Yixiao; Lazaris, Charalampos; Sakellaropoulos, Theodore et al. (2018) Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nat Commun 9:542

Showing the most recent 10 out of 1170 publications