The Genomics Facility combines the expertise and instrumentation of two previous shared resource laboratories, the Microarray Facility and the Molecular Diagnosis and Genotyping Facility, to provide an integrated set of services for DNA and RNA profiling. These services are delivered by experienced genomics professionals, including a newly strengthened and focused bioinformatics support staff. Abramson Cancer Center (ACC) members benefit from consultations and training available throughout their projects, including during experimental design and budget development, sample accrual. Facility quality control assays and lab work, data management and analyses, and manuscript preparation. The Facility supports quantitative RNA profiling by Affymetrix GeneChips, lllumina BeadChips, real-time PCR, Sequenom custom multiplex assays, and High-Throughput Genomics custom profiling. DNA profiling of custom panels of sequence polymorphisms are conducted by quantitative PCR, Sequenom assays, and lllumina GoldenGate genotyping, while whole-genome assays are available on Affymetrix SNP GeneChip and lllumina Infinium platforms. Several other services including microRNA profiling, epigenetic DNA assays, and translational molecular diagnostics for clinical research are offered using these platforms. Massively parallel sequencing on an lllumina Solexa Genome Analyzer expands existing assays with genomic coverage and resolution not previously possible, and creates opportunities for new genomics applications in cancer biology. The integration of all these services facilitates gene discovery, functional characterization, and other basic research efforts to elucidate the molecular pathogenesis of human cancers. In addition, molecular profiling at the DNA and RNA levels can be used to assist Abramson Cancer Center investigators in cancer diagnosis, subclassification, risk prediction and selection of appropriate therapy. Over 70 ACC members used the facility in the last year. ACC member usage was 34% of the total core usage. CCSG support represents 8% of the proposed core budget with the remaining funding from charge backs, grants/contracts, and institutional support.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Pennsylvania
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Echevarría-Vargas, Ileabett M; Reyes-Uribe, Patricia I; Guterres, Adam N et al. (2018) Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO Mol Med 10:
Torre, Eduardo; Dueck, Hannah; Shaffer, Sydney et al. (2018) Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH. Cell Syst 6:171-179.e5
Vonderheide, Robert H (2018) The Immune Revolution: A Case for Priming, Not Checkpoint. Cancer Cell 33:563-569
Romero, Sally A D; Jones, Lee; Bauml, Joshua M et al. (2018) The association between fatigue and pain symptoms and decreased physical activity after cancer. Support Care Cancer 26:3423-3430
Safo, Sandra E; Li, Shuzhao; Long, Qi (2018) Integrative analysis of transcriptomic and metabolomic data via sparse canonical correlation analysis with incorporation of biological information. Biometrics 74:300-312
Kall, Stefanie L; Delikatny, Edward J; Lavie, Arnon (2018) Identification of a Unique Inhibitor-Binding Site on Choline Kinase ?. Biochemistry 57:1316-1325
Bart, Stephen M; Cohen, Courtney; Dye, John M et al. (2018) Enhancement of Ebola virus infection by seminal amyloid fibrils. Proc Natl Acad Sci U S A 115:7410-7415
Quast, Lauren F; Phillips, Peter C; Li, Yimei et al. (2018) A prospective study of family predictors of health-related quality of life in pediatric brain tumor survivors. Pediatr Blood Cancer 65:e26976
Ecker, Christopher; Guo, Lili; Voicu, Stefana et al. (2018) Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep 23:741-755
Alexander, Erica S; Mick, Rosemarie; Nadolski, Gregory J et al. (2018) Combined chemoembolization and thermal ablation for the treatment of metastases to the liver. Abdom Radiol (NY) 43:2859-2867

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