The mission of the Human Immunology Core (HIC) is to provide human immune assays and expertise to facilitate immunoassessment of clinical trials, and specimens and reagents to facilitate basic and translational research that enhances our understanding of the tumor microenvironment and the host immune response. During the previous five years the HIC has supported 25 early stage clinical trials. The HIC facility is directed by Cari June, Professor of Pathology and Laboratory Medicine. Dr. June is recognized for his contributions to basic human immunology and for leadership in translational and therapeutic human cancer immunotherapy. Dr. Jean Boyer serves as Technical Director of the facility. Dr. Boyer is an expert in the assessment of clinical cellular immune responses to vaccines and immunotherapy and oversees an experienced staff. Specifically the staff provides relevant immunologic assays and reagents for basic and clinical research. The HIC services include providing purified primary human blood cell subsets, and annotated specimen handling and storage. The range of services provided by the HIC staff also includes proliferation assays, multinational lymphocyte subset analysis by flow cytometry, as well as a number of assays to assess lymphocyte activation and specificity. Lymphocytes can be assessed by the quantitative and sensitive ELISpot assay, TCR repertoire, or by multiparameter techniques, intracellular cytokine staining and luminex bead array technology. Importantly, the staff works closely with each PI to be sure that the immunological assays are optimally matched to each clinical trial. The specific approach and assays that are applied to each clinical trial are discussed with the PI to most efficiently address the goals of the respective trial. The nature of the current immunological assays requires that an expert staff be available to perform assays and have knowledge of the instrumentation. Finally, the HIC can perform all studies on a pilot research basis, or at the standard of Good Laboratory Practices, as appropriate for the particular needs of the trial. By facilitating the immunoassessment of clinical cancer trials, the HIC supports clinical and translational scientists. By providing access to patient biopsy specimens, the HIC also facilitates research on the tumor microenvironment, thereby supporting the research of basic scientists as well. Over 40 ACC members have used the core in the last year. ACC member usage is 48% of the total core usage. CCSG support represents 21% of the proposed core budget with the remaining funding coming from charge backs and institutional support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-38
Application #
8593274
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
38
Fiscal Year
2014
Total Cost
$210,169
Indirect Cost
$86,401
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Torre, Eduardo; Dueck, Hannah; Shaffer, Sydney et al. (2018) Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH. Cell Syst 6:171-179.e5
Echevarría-Vargas, Ileabett M; Reyes-Uribe, Patricia I; Guterres, Adam N et al. (2018) Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO Mol Med 10:
Romero, Sally A D; Jones, Lee; Bauml, Joshua M et al. (2018) The association between fatigue and pain symptoms and decreased physical activity after cancer. Support Care Cancer 26:3423-3430
Vonderheide, Robert H (2018) The Immune Revolution: A Case for Priming, Not Checkpoint. Cancer Cell 33:563-569
Kall, Stefanie L; Delikatny, Edward J; Lavie, Arnon (2018) Identification of a Unique Inhibitor-Binding Site on Choline Kinase ?. Biochemistry 57:1316-1325
Safo, Sandra E; Li, Shuzhao; Long, Qi (2018) Integrative analysis of transcriptomic and metabolomic data via sparse canonical correlation analysis with incorporation of biological information. Biometrics 74:300-312
Quast, Lauren F; Phillips, Peter C; Li, Yimei et al. (2018) A prospective study of family predictors of health-related quality of life in pediatric brain tumor survivors. Pediatr Blood Cancer 65:e26976
Bart, Stephen M; Cohen, Courtney; Dye, John M et al. (2018) Enhancement of Ebola virus infection by seminal amyloid fibrils. Proc Natl Acad Sci U S A 115:7410-7415
Ecker, Christopher; Guo, Lili; Voicu, Stefana et al. (2018) Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep 23:741-755
Alexander, Erica S; Mick, Rosemarie; Nadolski, Gregory J et al. (2018) Combined chemoembolization and thermal ablation for the treatment of metastases to the liver. Abdom Radiol (NY) 43:2859-2867

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