The Melanoma and Cutaneous Malignancies Program is a multidisciplinary Research Program that has been supported by the NCI CCSG since 1978. It provides the organizational structure and research forum for the efficient conduct of collaborative basic, clinical, and epidemiologic research in melanoma, basal and squamous cell carcinoma, and cutaneous T-cell lymphoma. Lynn Schuchter, MD has been Program Leader since 2007, after being an active member since 1989. John Seykora, MD, PhD was appointed Co-Leader in 2014 given the expansion of the Program into non-melanoma skin cancers. Members have a high degree of collaboration with other Research Programs and extramural investigators. The primary goal of the Program is to improve survival and quality of life for patients with melanoma, non-melanoma skin cancers and CTCL through basic, translational, and clinical epidemiological research. Three highly translational thematic areas of scientific focus include: epidemiology and risk assessment; the biology of cutaneous malignancies; and experimental therapeutics, including both targeted and immunotherapeutic approaches. The cohesiveness of the Program is maintained through several collaborative mechanisms (monthly research meetings, weekly tumor boards, monthly research in progress meetings, a yearly retreat sponsored by the Cancer Center) and NCI-funded multi-investigator research grants. The Program's 26 members are drawn from 11 departments from Penn's Perelman School of Medicine and two departments from The Wistar Institute. Critically important resources have been developed by Program members, and are supported by the Cancer Center, which have fostered the highly productive, translational research that distinguishes this Program. The resources include a comprehensive melanoma database; a melanoma pathology archive, from which investigators can access annotated pathology slides and blocks (normal skin and lesions) of patients seen as far back as 30 years ago; and a large biorepository of thousands of collected blood and tumor samples from patients with cutaneous lymphoma. During the project period, the Program has been remarkably productive with numerous investigator-initiated clinical trials and publications in high impact journals including New England Journal of Medicine, Journal of Clinical Oncology, Cell, and Journal of Clinical Investigation. The success of these efforts is reflected in the award of an NCI Skin Cancer SPORE and additional grants in laboratory-based translational and population science research, including two NCI P01 grants to support innovative clinical/translational research. In total, members have $4.1M in research funding (annual direct costs) of which $2.3M is peer- reviewed and $1.5 is from the NCI. During the project period, members published 373 cancer-related publications, of which 22% were intra-Programmatic, 30% were inter-Programmatic and 58% were multi- institutional.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-43
Application #
9618143
Study Section
Subcommittee I - Career Development (NCI)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
43
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Liu, Wei; Krump, Nathan A; MacDonald, Margo et al. (2018) Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts. J Virol 92:
Schapira, Marilyn M; Barlow, William E; Conant, Emily F et al. (2018) Communication Practices of Mammography Facilities and Timely Follow-up of a Screening Mammogram with a BI-RADS 0 Assessment. Acad Radiol 25:1118-1127
Morrison, Alexander H; Byrne, Katelyn T; Vonderheide, Robert H (2018) Immunotherapy and Prevention of Pancreatic Cancer. Trends Cancer 4:418-428
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Yan, Lesan; Amirshaghaghi, Ahmad; Huang, Dennis et al. (2018) Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Adv Funct Mater 28:
Waxman, Adam J; Clasen, Suparna; Hwang, Wei-Ting et al. (2018) Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis. JAMA Oncol 4:e174519
Han, Joseph; Lachance, Catherine; Ricketts, M Daniel et al. (2018) The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. J Biol Chem 293:4498-4509
Reshef, Ran; Ganetsky, Alex; Acosta, Edward P et al. (2018) Extended CCR5 Blockade for Graft-versus-Host Disease Prophylaxis Improves Outcomes of Reduced-Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial. Biol Blood Marrow Transplant :
Gangadhar, Tara C; Savitch, Samantha L; Yee, Stephanie S et al. (2018) Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma. Pigment Cell Melanoma Res 31:73-81
Rosenfeld, Aaron M; Meng, Wenzhao; Luning Prak, Eline T et al. (2018) ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data. Front Immunol 9:2107

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