DEVELOPMENTAL FUNDS: ABSTRACT Developmental Funds of $50,000 are requested to provide an essential foundation of support for the Cancer Center's investment in emerging scientific and technological opportunities. As part of the planning and evaluation process, KCI links its strategic objectives with programmatic priorities and targets funding to specific developmental goals in: 1) support of innovative pilot projects; 2) recruitment of faculty-level scientists; 3) development of programs that train researchers and sustain a vigorous portfolio of external funding; 4) support of developing Shared Resources; and 5) providing Core vouchers that encourage the use of Cancer Center Shared Resources by junior faculty and those wishing to explore innovative, otherwise unfunded research. CCSG Developmental Funds During the period of 12/1/2010 to 5/31/2014, three developing Shared Resources were supported with $187,372 of CCSG Developmental Funds: Animal Model and Therapeutics Evaluation Core (AMTEC), Translational Sciences Core (TSC), and Clinical Imaging Research Core (CIRC). The AMTEC developing Core is being submitted as a new, full Core in this competing renewal application. The TSC developing Core is being integrated into the Biorepository Core (which has been re-named Biobanking and Correlative Sciences Core). The CIRC has been discontinued as a developing Core with the concurrence of our EAB. WSU/KCI Institutional Support for Developmental Fund Activities During the period of 12/1/2010 to 5/31/2014, institutional support provided a total of $11.5 million in funds. With the use of these funds, the Cancer Center has achieved a remarkable return on investment: ? Investing in annual pilot funding for innovative projects. A total of $985,232 was invested in pilot projects, yielding eleven extramural awards, totaling $9,989,542. ? Supporting the recruitment of faculty level scientists. A total of $7,918,013 was provided from a combination of KCI and WSU institutional support for 42 new faculty members' salaries and lab support during the past three-and-a-half years. These new faculty level scientists have generated a total of 211 publications, 32 grant awards, and 85 clinical trials since their arrival. ? Establishing a post-doctoral research training program. A total of $215,908 supported 8 post-doctoral fellows, resulting in the recruitment of one faculty level scientist. ? Creating a mock study section program. A total of $5,400 in stipends to reviewers was provided from institutional support, resulting in $1,580,044 of extramural funding. ? Nurturing three new Shared Resources. A total of $2,330,214 was provided from institutional support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA022453-38
Application #
9836628
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
38
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Kraniak, Janice M; Chalasani, Anita; Wallace, Margaret R et al. (2018) Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Exp Neurol 299:289-298
An, Myunggi; Yu, Chunsong; Xi, Jingchao et al. (2018) Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity. Nanoscale 10:9311-9319
Neslund-Dudas, Christine M; McBride, Russell B; Kandegedara, Ashoka et al. (2018) Association between cadmium and androgen receptor protein expression differs in prostate tumors of African American and European American men. J Trace Elem Med Biol 48:233-238
Wu, Jheng-Yu; Xiang, Shengyan; Zhang, Mu et al. (2018) Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem 293:1976-1993
Negmeldin, Ahmed T; Knoff, Joseph R; Pflum, Mary Kay H (2018) The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity. Eur J Med Chem 143:1790-1806
Tamura, Koji; Yu, Jun; Hata, Tatsuo et al. (2018) Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A 115:4767-4772
Matherly, Larry H; Hou, Zhanjun; Gangjee, Aleem (2018) The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. Cancer Chemother Pharmacol 81:1-15
Pollack, Murray M; Holubkov, Richard; Reeder, Ron et al. (2018) PICU Length of Stay: Factors Associated With Bed Utilization and Development of a Benchmarking Model. Pediatr Crit Care Med 19:196-203
Bao, Xun; Wu, Jianmei; Sanai, Nader et al. (2018) A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor. J Pharm Anal 8:20-26
Heath, Elisabeth I; Lynce, Filipa; Xiu, Joanne et al. (2018) Racial Disparities in the Molecular Landscape of Cancer. Anticancer Res 38:2235-2240

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