; The program leaders and co-leaders of the Purdue University Center for Cancer Research includes Drs. Elizabeth Taparowsky and David Riese function as leader and co-leader, respectively, of the Cell Growth and Differentiation Program. Drs. Cynthia Stauffacher and David Thompson are leader and co-leader, respectively, of the Chemical and Structural Biology Program. Drs. Richard Gibbs and Deborah Knapp are leader and co-leader of the Medicinal Chemistry Program and Drs Donald Bergstrom and Alex Wei are leader and co-leader of the Drug Delivery and Molecular Sensing Program. These leaders have distinguished and highly collaborative research laboratories and have functioned to guide their respective programs. They organize programmatic meetings, set goals, mentor members and encourage transdisciplinary participation in research efforts. Further, all serve on the primary decision making body of the Center, the Executive Committee. In this capacity all provide input on major decision of the Center and thus, contribute to determining the future mission of the Center.

Public Health Relevance

The program leaders and co-leaders provide vision, resources and organizational capacity for the Center that enables the pursuit of collaborative research. The collaborative efforts bring together scientists from many disciplines to address cancer-related problems. Throught these transdisciplinary investigations, novel discoveries are made that lead to improvement in early detection and care of cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-34
Application #
8681159
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Lin, Clement; Wu, Guanhui; Wang, Kaibo et al. (2018) Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures. Angew Chem Int Ed Engl 57:10888-10893
Hsu, Alan Y; Gurol, Theodore; Sobreira, Tiago J P et al. (2018) Development and Characterization of an Endotoxemia Model in Zebra Fish. Front Immunol 9:607
Li, Zhiguo; Kong, Yifan; Song, Longzhen et al. (2018) Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin. Cancer Res 78:2864-2875
Xiong, Yan; Yue, Feng; Jia, Zhihao et al. (2018) A novel brown adipocyte-enriched long non-coding RNA that is required for brown adipocyte differentiation and sufficient to drive thermogenic gene program in white adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids 1863:409-419
Mani, Saravana Kumar Kailasam; Andrisani, Ourania (2018) Hepatitis B Virus-Associated Hepatocellular Carcinoma and Hepatic Cancer Stem Cells. Genes (Basel) 9:
Zhou, Wenqing; Pal, Arpita S; Hsu, Alan Yi-Hui et al. (2018) MicroRNA-223 Suppresses the Canonical NF-?B Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Rep 22:1810-1823
Dayal, Neetu; Opoku-Temeng, Clement; Hernandez, Delmis E et al. (2018) Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines. Future Med Chem 10:823-835
Onel, Buket; Carver, Megan; Agrawal, Prashansa et al. (2018) The 3'-end region of the human PDGFR-? core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes. Biochim Biophys Acta Gen Subj 1862:846-854
Sorlien, Erin L; Witucki, Mary A; Ogas, Joseph (2018) Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio. J Vis Exp :
Mani, Saravana Kumar Kailasam; Andrisani, Ourania (2018) Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma. Cytokine :

Showing the most recent 10 out of 436 publications