The Purdue University Center for Cancer Research (PCCR) was established as a National Cancer Institute basic science cancer center in 1978. As a NCI basic science cancer center, the PCCR's mission focuses on basic discovery - discovery through Foundational Disciplines that the PCCR fosters for innovative cancer solutions. The PCCR has a robust process for the use of developmental funds. During the last project period, the PCCR used the developmental funds to further strengthen cancer-related science within the Purdue Center for Cancer Research (PCCR), primarily through support of faculty recruitment and through support of the Computational & Medicinal Chemistry Shared Resource (CMC-SR). Through the direction of PCCR leadership, developmental and additional funds and space were used to directly support recruitment of 10 new faculty (6 junior and 4 senior) into the Cell Identity and Signaling (CIS), and Targets, Structures and Drugs (TSD) Research Programs. In the proposed project period, the PCCR proposes the following specific aim:
Aim 1 : Recruit faculty members into the PCCR, with a major emphasis on faculty in computational genomics and bioinformatics, and cancer biology. An emphasis will be placed on recruiting senior investigators in the area of computational biology or cancer therapeutics, as well as in the area of analytical chemistry and biophysics, with a cancer focus.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023168-40
Application #
10024923
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-08-01
Budget End
2021-06-30
Support Year
40
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112
Dhawan, Deepika; Hahn, Noah M; Ramos-Vara, José A et al. (2018) Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet 14:e1007571
Shinde, Aparna; Libring, Sarah; Alpsoy, Aktan et al. (2018) Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Mol Cancer Res 16:1579-1589
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876

Showing the most recent 10 out of 436 publications