? TUMOR MICROENVIRONMENT AND METASTASIS The overarching goals of the Tumor Microenvironment and Metastasis (TMEM) Program are to define how the interplay between cancer cells, stromal components, and the ECM creates an environment permissive for tumor growth and metastasis, and to use this knowledge to facilitate the development of new and more effective cancer therapies. The TMEM Program was reconfigured in 2013 during the restructuring of the Sanford-Burnham Medical Research Institute (SBMRI) Cancer Center, which brought together members of the former Tumor Microenvironment Program and investigators interested in the immune and inflammatory components of the tumor microenvironment, who were previously members of other programs. The Program consists of 15 faculty (two of whom are new recruits) and four adjunct members, with expertise in structural biology, carbohydrate chemistry, cryo-electron microscopy, computational analysis, signal transduction, integrin biology, animal models of tumor growth and metastasis, innate and adaptive immune mechanisms, and functional chemical genomic strategies for target identification. The complementary expertise brought by program faculty is organized around three interacting themes: Angiogenesis and Immune/inflammatory Modulation; Cell Migration, Invasion and Metastasis; and Defining New Intervention Points for Cancer Therapy. Members interact at a number of levels, including monthly faculty meetings, program-led seminars (18 in the last funding period), strategic meetings organized around new collaborative opportunities (for example, the interface of the human microbiome and cancer), and collaborative grants. Program funding is strong, with current total annual grant funding of $6.1M (direct costs). Members currently lead 34 grants including 13 R01s (8 from NCI), 3 U01s (2 from NCI), and lead or participate in 5 P01s (2 from NCI), and multiple other grants (DOD, Komen, SU2C). 14 (41%) of the grants are collaborative and multi-investigator. Our productivity is reflected in 261 cancer-relevant publications in the last funding period, of which 27% were collaborative (16% intra- and 12% inter-programmatic). In 2013 alone, we published 52 cancer-relevant publications, of which 21% were intra- and 12% inter-programmatic. In addition, program members contribute to the Cancer Center as Scientific Directors of five Shared Resources (Animal Resources, Cell Imaging and Histology, Flow Cytometry, Functional Genomics, and Structural Biology).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA030199-36
Application #
9364584
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
36
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Sanford Burnham Prebys Medical Discovery Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Wei, Yang; Toth, Julia I; Blanco, Gabrielle A et al. (2018) Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors. J Biol Chem 293:20169-20180
Tinoco, Roberto; Carrette, Florent; Henriquez, Monique L et al. (2018) Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol 200:2690-2702
Wonder, Emily; Simón-Gracia, Lorena; Scodeller, Pablo et al. (2018) Competition of charge-mediated and specific binding by peptide-tagged cationic liposome-DNA nanoparticles in vitro and in vivo. Biomaterials 166:52-63
Limpert, Allison S; Lambert, Lester J; Bakas, Nicole A et al. (2018) Autophagy in Cancer: Regulation by Small Molecules. Trends Pharmacol Sci 39:1021-1032
Fujita, Yu; Khateb, Ali; Li, Yan et al. (2018) Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis. Cell Rep 24:3296-3311.e6
Scully, Kathleen M; Lahmy, Reyhaneh; Signaevskaia, Lia et al. (2018) E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol 6:181-198
Borlido, Joana; Sakuma, Stephen; Raices, Marcela et al. (2018) Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol 19:594-605
Follis, Ariele Viacava; Llambi, Fabien; Kalkavan, Halime et al. (2018) Regulation of apoptosis by an intrinsically disordered region of Bcl-xL. Nat Chem Biol 14:458-465
Pathria, Gaurav; Scott, David A; Feng, Yongmei et al. (2018) Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. EMBO J 37:
Sun, Younguk; Chen, Bo-Rui; Deshpande, Aniruddha (2018) Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia. Front Oncol 8:41

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