Community Outreach and Engagement ABSTRACT The City of Hope Comprehensive Cancer Center (COHCCC) is a freestanding cancer center whose main campus is located in Duarte, California. The COHCCC Catchment Area includes the entirety of Los Angeles and Orange Counties and portions of Ventura, Riverside, and San Bernardino Counties. The Catchment Area is bounded by the Pacific Ocean to the south and west; Antelope Valley to the north; Santa Clarita and Simi Valley to the west; the metropolitan areas of Riverside and San Bernardino to the east; and the communities of Palm Desert, Murrieta, and San Clemente to the south. The COHCCC Catchment Area covers 9,365 square miles and includes the heart of the greater Los Angeles metropolitan area and more inland communities. We serve a multi-racial, multi-ethnic community of over 17.1 million individuals, which represents approximately 40 percent of all Californians. Remarkably, the population of our Catchment Area is greater than the individual populations of 46 states and greater than the populations of 14 states combined. The COHCCC seeks to use its research and resources to improve the lives of the men, women, and children who live in our Catchment Area, particularly in the more inland regions. The residents we serve face challenges that impact cancer survival, including poverty, obesity, and lack of access. These challenges are uniformly faced whether an individual comes from urban or more rural environments. To achieve this goal, COHCCC has three themes: 1. Identify and pursue challenging questions in cancer research relevant to the people of our Catchment Area. 2. Develop and implement strategies for including underserved populations in our programmatic research. 3. Take advantage of research discoveries, collaborations, networks, and affiliates to extend our reach and to implement creative interventions to increase access and health equity within our Catchment Area, as well as nationally and internationally. To reduce the incidence of cancer in the unique populations we serve within our Catchment Area, we identified the following priorities: ? Biologically aggressive cancers that impact diverse populations in our COHCCC Catchment Area ? Viral-related cancers, including hepatocellular carcinoma and HIV-related malignancies ? Impact of pollution on cancer incidence, with a focus on breast and lung cancer ? Cancers of aging in Asian- and Latino-Americans

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-37
Application #
9849216
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Slavin, Thomas P; Banks, Kimberly C; Chudova, Darya et al. (2018) Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing. J Clin Oncol :JCO1800328
Yun, Xinwei; Zhang, Keqiang; Wang, Jinhui et al. (2018) Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma. Mol Cancer Res 16:1161-1171
Herrera, Alex F; Rodig, Scott J; Song, Joo Y et al. (2018) Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma. Biol Blood Marrow Transplant 24:514-520
Oh, Eunjin; Ahn, Miwon; Afelik, Solomon et al. (2018) Syntaxin 4 Expression in Pancreatic ?-Cells Promotes Islet Function and Protects Functional ?-Cell Mass. Diabetes 67:2626-2639
Shahin, Sophia A; Wang, Ruining; Simargi, Shirleen I et al. (2018) Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine 14:1381-1394
Wittenberg, Elaine; Ferrell, Betty; Koczywas, Marianna et al. (2018) Pilot Study of a Communication Coaching Telephone Intervention for Lung Cancer Caregivers. Cancer Nurs 41:506-512
Zhang, Keqiang; Wang, Jinhui; Yang, Lu et al. (2018) Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1? and APC2 gene expression in non-small cell lung cancer. Mol Cancer 17:153
Zhang, Bin; Nguyen, Le Xuan Truong; Li, Ling et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nat Med 24:450-462
Kirschbaum, Mark H; Frankel, Paul; Synold, Timothy W et al. (2018) A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study. Br J Haematol 180:445-448
Liu, Liang; Yang, Lin; Yan, Wei et al. (2018) Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis. Clin Cancer Res 24:2370-2382

Showing the most recent 10 out of 1396 publications