The Program in the Nuclear Control of Cell Growth and Differentiation emphasizes research on the basic biological regulatory processes that maintain genome stability and regulate gene expression. The faithful inheritance and readout genetic information involves many regulated processes including DNA replication and repair, RNA synthesis and processing and protein synthesis. Members of this program investigate the molecular basis of these processes by a combination of approaches spanning from traditional genetics to biophysical techniques. Genetic analyses in model systems have led to discoveries of new genes and their functions. On the other hand, biochemical and biophysical studies of regulatory proteins are ongoing in many arenas. Experimental systems include bacteria, yeast, Drosophila, C. elegans, mouse, zebrafish and humans as well as bacteriophages and animal viruses. These fundamental processes employ the same molecular mechanisms that are dysregulated in cancer. Many research projects are focused directly on cancer biology while others are exploiting model systems to discover the molecules that execute basic biological regulatory events.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-13
Application #
6334949
Study Section
Project Start
2000-07-25
Project End
2001-04-30
Budget Start
Budget End
Support Year
13
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Tavtigian, Sean V; Greenblatt, Marc S; Harrison, Steven M et al. (2018) Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework. Genet Med 20:1054-1060
Rogers, R Aaron; Fleming, Aaron M; Burrows, Cynthia J (2018) Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence. Biophys J 114:1804-1815
Rogers, R Aaron; Fleming, Aaron M; Burrows, Cynthia J (2018) Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters. ACS Omega 3:9630-9635
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Trott, Daniel W; Henson, Grant D; Ho, Mi H T et al. (2018) Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp Gerontol 109:99-107
Wu, Yelena P; Parsons, Bridget G; Mooney, Ryan et al. (2018) Barriers and Facilitators to Melanoma Prevention and Control Behaviors Among At-Risk Children. J Community Health 43:993-1001

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