BIOREPOSITORY AND MOLECULAR PATHOLOGY SHARED RESOURCE ABSTRACT The Biorepository and Molecular Pathology (BMP) Shared Resource, established in 2000, seamlessly integrates exceptional expertise in biorepository, histology, and molecular diagnostic services for research at Huntsman Cancer Institute (HCI). The College of American Pathologists (CAP)-accredited Biorepository Section provides researchers with high quality, richly annotated fresh tumor, blood, and other body fluids with patient-matched normal controls, using adept procurement, processing, storage, and prioritized distribution. The biorepository is responsible for managing patient consent and IRB approval. Data entry, searches, and annotation of biospecimens with pathology, electronic medical record, genealogical (via the Utah Population Database Shared Resource), genomic (via the High-Throughput Genomics and Bioinformatic Shared Resource), and tumor registry data are all provided via the itBioPath software system used by the BMP Shared Resource (and built by the Research Informatics Shared Resource). The Research Histology Section is separate from hospital histology, facilitating dedicated and rapid turnaround for research. Research Histology performs all manner of expert histology on Biorepository frozen and fixed human and animal tissues, including tissue microarray work, processing, frozen and paraffin sectioning, and special staining from a catalogue of over 175 immuno- and histochemical options. The Molecular Diagnostic Section provides an essential bridge from scientific discovery to patient trials prior to CLIA test certification. It uses biospecimens and histologic preparations from the other two BMP sections for nucleic acid isolation and genetic analysis via Sequenom MassArray and Illumina MiSeq technologies. Data are uploaded to GNomEx, HCI's centralized genomics database. The BMP Shared Resource is directed by Evin Gulbahce, MD, who oversees daily operations and provides essential, pathologist-specific expertise to the Resource. The BMP resides partially in the Cancer Hospital adjacent to pathology/operating rooms to facilitate rapid fresh tissue banking, with the Biorepository section on the third floor of the research building directly adjacent to laboratories. The BMP Shared Resource markedly advances efficiency and cost savings for cancer research at HCI, providing precious, highly annotated biospecimens, histology, and molecular diagnostics which add substantial value to HCI's research efforts and advance HCI?s goals to improve cancer diagnosis, treatment, and cure. The importance of the Resource is demonstrated by its wide array of users and its contributions to numerous publications. In 2013, use of the Resource by Cancer Center investigators with peer-reviewed funding exceeded 43%, while the CCSG budget request is only 6% ($61,944) of the total proposed budget.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-28
Application #
9273912
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
28
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Liang, Wenjie; Yang, Pengfei; Huang, Rui et al. (2018) A Combined Nomogram Model to Preoperatively Predict Histologic Grade in Pancreatic Neuroendocrine Tumors. Clin Cancer Res :
Ou, Judy Y; Fowler, Brynn; Ding, Qian et al. (2018) A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population. BMC Cancer 18:115
Peres, Lauren C; Cushing-Haugen, Kara L; Anglesio, Michael et al. (2018) Histotype classification of ovarian carcinoma: A comparison of approaches. Gynecol Oncol 151:53-60
Vázquez-Arreguín, Karina; Maddox, Jessica; Kang, Jinsuk et al. (2018) BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Mol Cancer Res 16:439-452
Himbert, Caroline; Ose, Jennifer; Nattenmüller, Johanna et al. (2018) Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study. Cancer Epidemiol Biomarkers Prev :
Zeng, Tao; Fleming, Aaron M; Ding, Yun et al. (2018) Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA. J Org Chem 83:3973-3978
Arbeeva, Liubov S; Hanson, Heidi A; Arbeev, Konstantin G et al. (2018) How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database. Front Public Health 6:277
Madison, Bethany J; Clark, Kathleen A; Bhachech, Niraja et al. (2018) Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. J Biol Chem 293:18624-18635
De, Shrutokirti; Van Deren, Donn; Peden, Eric et al. (2018) Two distinct ontogenies confer heterogeneity to mouse brain microglia. Development 145:
Patel, Ami B; Lange, Thoralf; Pomicter, Anthony D et al. (2018) Similar expression profiles in CD34+ cells from chronic phase chronic myeloid leukemia patients with and without deep molecular responses to nilotinib. Oncotarget 9:17889-17894

Showing the most recent 10 out of 1193 publications