The goal of the Migration and Metastasis Program is to create an intellectual and scientific environment that facilitates and enhances progress towards understanding the basic processes that underlie metastasis, and design and test strategies for intervention in these processes. Understanding the molecular and cellular basis for metastasis requires defining the changes that cells undergo during cancer progression. This Program focuses on how changes in extracellular matrix, adhesion proteins, adhesion activated signaling pathways and changes in gene expression drive the fundamental steps in metastasis. Research in the Program emphasizes understanding these complex processes in cancer cells/tumors and in the context of normal cell/tissue interactions. The Program is comprised of 18 investigators from 7 Departments. Importantly, 11 of the investigators are new to this Program since the last renewal. The Program has coalesced around two fundamental migration/metastasis-related themes: first, cell-cell and cell-matrix interactions, adhesion signaling and migration/metastasis;and second, the role of extracellular matrix molecules in cell adhesion, cell differentiation and vasculogenesis. The accomplishments of the Program include, understanding Integrin signaling and vasculogenesis, assembly and turnover of cellular adhesions and cell migration, integrin signals and DNA damage, E-cadherin-beta catenin signaling in cancer cells, function of ADAMS proteins, understanding problems of host-tumor microenvironment and numerous authoratative reviews on aspects of migration and metastasis. Because cell migration is so key to the cancer problem, the Program provides intellectual and technical resources to many individuals within the Cancer Center. Program members are experts in cellular imaging, in vivo imaging, use of biosensors for real time imaging, gene array analysis, protein analysis and purification, mechanotransduction, and animal models for cancer. The intellectual vitality of the Program is supported by numerous seminars focusing on problems of cell migration, adhesion, ECM and cell signaling, journal clubs, """"""""research in progress meetings"""""""" and membership on student thesis committees. The members of this Program have published 331 papers since the last renewal, of which 5% are intra-programmatic and 20% are inter-programmatic. In the current budget year, the members of this Program are responsible for $480K in direct costs from NCI-funded awards, out of a peer reviewed direct cost funding total of $9.7M. Total NIH funding has increased four-fold since the last renewal. In summary, Program 4-Migration and Metastasis is an exceptional, scientifically active Program whose members make significant contributions to understanding the fundamental processes of cell migration and cancer cell metastasis and significantly contribute to the mission of the CCSG and Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA044579-20
Application #
8104143
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
20
Fiscal Year
2010
Total Cost
$23,111
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Borten, Michael A; Bajikar, Sameer S; Sasaki, Nobuo et al. (2018) Automated brightfield morphometry of 3D organoid populations by OrganoSeg. Sci Rep 8:5319
Olson, Kristine C; Kulling Larkin, Paige M; Signorelli, Rossana et al. (2018) Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. Cytokine 111:551-562
Pfister, Katherine; Pipka, Justyna L; Chiang, Colby et al. (2018) Identification of Drivers of Aneuploidy in Breast Tumors. Cell Rep 23:2758-2769
Carhart, Miev Y; Schminkey, Donna L; Mitchell, Emma M et al. (2018) Barriers and Facilitators to Improving Virginia's HPV Vaccination Rate: A Stakeholder Analysis With Implications for Pediatric Nurses. J Pediatr Nurs 42:1-8
Hao, Yi; Bjerke, Glen A; Pietrzak, Karolina et al. (2018) TGF? signaling limits lineage plasticity in prostate cancer. PLoS Genet 14:e1007409
Obeid, Joseph M; Kunk, Paul R; Zaydfudim, Victor M et al. (2018) Immunotherapy for hepatocellular carcinoma patients: is it ready for prime time? Cancer Immunol Immunother 67:161-174
Wallrabe, Horst; Svindrych, Zdenek; Alam, Shagufta R et al. (2018) Segmented cell analyses to measure redox states of autofluorescent NAD(P)H, FAD & Trp in cancer cells by FLIM. Sci Rep 8:79
Olmez, Inan; Love, Shawn; Xiao, Aizhen et al. (2018) Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. Neuro Oncol 20:192-202
Wang, T Tiffany; Yang, Jun; Zhang, Yong et al. (2018) IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective ?-chain cytokines, decreases leukemic T-cell viability. Leukemia :
Yao, Nengliang; Zhu, Xi; Dow, Alan et al. (2018) An exploratory study of networks constructed using access data from an electronic health record. J Interprof Care :1-8

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