The Animal Shared Resource offers integral support to CSHL Cancer Center members by providing high quality animal housing, husbandry services, and technical and managerial support to cover all aspects of animal care and use such as tissue biopsies, colony management and protocol implementation. In addition, highly trained personnel teach a variety of specialty skills to researchers, including surgical manipulations and post surgery monitoring, blood and tissue procurement, cesarean re-derivation, tissue perfusion, and therapeutic and virus administration. The veterinary skills of the Animal Shared Resource enable researchers to generate new and innovative mouse cancer models including viral transduction models, multi-allele reversible cancer models, and organoid orthotopic engraftment models of human and mouse cancer. Furthermore, the Animal Shared Resource develops and provides training for implementing new animal protocols. The support provided by the Animal Shared Resource is absolutely fundamental for many research advances in the CSHL Cancer Center. It has enabled researchers to develop innovative animal models for cancer, which continue to be instrumental in uncovering the genetic and molecular basis of the disease. As the CSHL Cancer Center shifts to expand its preclinical and translational research, animal models will become even more important. The Animal Shared Resource enables researchers to move beyond cell culture and to explore cancer biology and cancer medicine in an appropriate in vivo context. In summary, the Animal Shared Resource provides the Cancer Center with a complete set of essential services and sophisticated technical support to facilitate cancer research and discovery. Over the past five years, a total of 27 Cancer Center members (73% of members) utilized the Animal Shared Resource, representing the majority of the facility's use. This Shared Resource contributed to 70 publications by Cancer Center members over this time period.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA045508-31
Application #
9518764
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
31
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
Bhagwat, Anand S; Lu, Bin; Vakoc, Christopher R (2018) Enhancer dysfunction in leukemia. Blood 131:1795-1804
Aberle, M R; Burkhart, R A; Tiriac, H et al. (2018) Patient-derived organoid models help define personalized management of gastrointestinal cancer. Br J Surg 105:e48-e60
Chen, Wei-Chia; Tareen, Ammar; Kinney, Justin B (2018) Density Estimation on Small Data Sets. Phys Rev Lett 121:160605
Khan, Jalal A; Maki, Robert G; Ravi, Vinod (2018) Pathologic Angiogenesis of Malignant Vascular Sarcomas: Implications for Treatment. J Clin Oncol 36:194-201
Albrengues, Jean; Shields, Mario A; Ng, David et al. (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361:
Cheng, Derek; Tuveson, David (2018) Kras in Organoids. Cold Spring Harb Perspect Med 8:
Melnikov, Sergey V; Rivera, Keith D; Ostapenko, Denis et al. (2018) Error-prone protein synthesis in parasites with the smallest eukaryotic genome. Proc Natl Acad Sci U S A 115:E6245-E6253
Cook, Natalie; Basu, Bristi; Smith, Donna-Michelle et al. (2018) A phase I trial of the ?-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma. Br J Cancer 118:793-801
Pommier, Arnaud; Anaparthy, Naishitha; Memos, Nicoletta et al. (2018) Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science 360:
Krishnan, Navasona; Bonham, Christopher A; Rus, Ioana A et al. (2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun 9:283

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