The Translational and Clinical Research (TACR) Program was established in early 2016 as a forward-looking, proactive response to an ongoing shift in translational and clinical cancer research away from disease-centric paradigms, and toward cross-disease site innovation and development. TACR represents the interface between basic science Programs and the clinic-based, disease-specific research groups and is designed to expedite the translation of innovative clinical approaches developed by University of Michigan Comprehensive Cancer Center (UMCCC) researchers to the clinic. The program is comprised of 69 members from 24 different departments representing 6 different schools and colleges. In 2016, TACR members had a total of $28.8M in annual (DC) cancer grant funding, of which $7M (24.3%) is from NCI, $2.7M (9.4%) is from other NIH, and $12.6M (43.7%), is total peer-reviewed. In addition, TACR members are supported by grants from drug and device companies with total funding of $14.5M (50.4%). Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other UMCCC programs within most of the Basic Science and Cancer Control and Population Sciences Programs. Members have a total of 1423 publications, of which 31.1% are intra-programmatic and 50.6% are inter-programmatic. The TACR program has three main Specific Aims: I) use state-of-the-art genomic approaches to make discoveries that advance patient care; II) Advance novel UMCCC concepts and agents into human trials to expedite the translation of laboratory discoveries to the clinic; and III) Develop and test new predictive biomarker and disease monitoring strategies for improving patient care.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
Program Officer
Belin, Precilla L
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University of Michigan Ann Arbor
Ann Arbor
United States
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Akkina, Sarah R; Kim, Roderick Y; Stucken, Chaz L et al. (2018) Is There a Difference in Staging and Treatment of Head and Neck Squamous Cell Tumors Between Tertiary Care and Community-Based Institutions? Laryngoscope Investig Otolaryngol 3:290-295
Anwar, Talha; Arellano-Garcia, Caroline; Ropa, James et al. (2018) p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis. Nat Commun 9:2801
Giraldez, Maria D; Spengler, Ryan M; Etheridge, Alton et al. (2018) Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol 36:746-757
Hartlerode, Andrea J; Regal, Joshua A; Ferguson, David O (2018) Reversible mislocalization of a disease-associated MRE11 splice variant product. Sci Rep 8:10121
Fritsche, Lars G; Gruber, Stephen B; Wu, Zhenke et al. (2018) Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. Am J Hum Genet 102:1048-1061
Haley, Henry R; Shen, Nathan; Qyli, Tonela et al. (2018) Enhanced Bone Metastases in Skeletally Immature Mice. Tomography 4:84-93
McClintock, Shannon D; Colacino, Justin A; Attili, Durga et al. (2018) Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements. Cancer Prev Res (Phila) 11:413-428
Spector, Matthew E; Farlow, Janice L; Haring, Catherine T et al. (2018) The potential for liquid biopsies in head and neck cancer. Discov Med 25:251-257
Giordano, Thomas J (2018) Genomic Hallmarks of Thyroid Neoplasia. Annu Rev Pathol 13:141-162
Harvey, Innocence; Stephenson, Erin J; Redd, JeAnna R et al. (2018) Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice. Endocrinology 159:2275-2287

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