(CANCER HEMATOPOIESIS AND IMMUNOLOGY) The mission of Cancer Hematopoiesis and Immunology (CHI) Program is hewed to the tenet of collaborative transdisciplinary research that is aligned with the UMCCC strategic research priorities. Members of the CHI Program are committed to the pursuit of research that defines the fundamental roles of immune and non- immune hematopoietic cells in cancer as well as post-transplantation therapies. Working under the broad theme of cellular and innate immunity, normal and malignant hematopoiesis, and hematopoietic stem cell transplantation biology, the CHI Program seeks to develop translational approaches that will improve hematopoietic cell transplantation (HCT) outcomes and hasten the development of novel vaccination strategies. Toward these goals, the CHI Program is a diverse, interdisciplinary research group comprised of 24 members from 10 departments within three University of Michigan schools/colleges. The CHI Program has $10.3M in annual direct funding (88% peer-reviewed), with $2.7M from the NCI, $5.3M from other NIH sources and $2.3M in additional support. During the past project period, the Program generated 376 publications, including high impact reports appearing in Cell, Nature, Science, NEJM, and the JCI. The CHI Program enjoys strong interactions with other UMCCC members, underlined by 24% of their publications arising from intra- programmatic efforts and 43% from inter-programmatic collaborations. To build on these advances, Program aims include: 1) elucidate molecular mechanisms regulating normal immune/non-immune hematopoietic cell function during homeostasis and their alterations in cancer and HCT, 2) characterize the role of the tissue microenvironment in controlling the function and regulation of immune cells in cancer, hematopoiesis and HCT and 3) define key concepts, approaches, and reagents in preclinical studies to translate the most compelling advances into the clinic via collaboration with the Translational and Clinical Research (TACR) Program. As such, CHI Program members support the UMCCC mission by performing state-of-the-art research underlying both major and less common cancer types within our catchment area, while training the next generation of cancer researchers, and promoting collaboration with other UMCCC Programs and beyond.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046592-30
Application #
9744583
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
30
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Schofield, Heather K; Zeller, Jörg; Espinoza, Carlos et al. (2018) Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight 3:
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Stoffel, Elena M; Koeppe, Erika; Everett, Jessica et al. (2018) Germline Genetic Features of Young Individuals With Colorectal Cancer. Gastroenterology 154:897-905.e1
Djuric, Zora; Bassis, Christine M; Plegue, Melissa A et al. (2018) Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations. J Acad Nutr Diet 118:606-616.e3
Mann, Jacqueline E; Smith, Joshua D; Birkeland, Andrew C et al. (2018) Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma. Cancer Immunol Immunother :
Jiagge, Evelyn; Jibril, Aisha Souleiman; Davis, Melissa et al. (2018) Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations. J Glob Oncol :1-8
Bowers, Emily; Slaughter, Anastasiya; Frenette, Paul S et al. (2018) Granulocyte-derived TNF? promotes vascular and hematopoietic regeneration in the bone marrow. Nat Med 24:95-102
Holt, Melissa C; Assar, Zahra; Beheshti Zavareh, Reza et al. (2018) Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry 57:6604-6614
Wang, Yin; Day, Mark L; Simeone, Diane M et al. (2018) 3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer. J Vis Exp :

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