The Cancer Prevention and Population Science (CPPS) research program, one of the three established research programs of the Cancer Therapy &Research Center (CTRC) at The University of Texas Health Science Center at San Antonio (UTHSCSA), has 17 members (13 primary, four secondary) who are focused on, and have made great strides in cancer prevention affecting the residents of San Antonio, South Texas, and the nation. The CPPS Program's key research themes are: eliminating cancer-related health disparities, especially among the region's predominantly Latino population;using cancer control to improve outcomes, especially focusing on children, adolescents, and young adults;and identifying the determinants of cancer and cancer risk and prognosis, especially focusing on prostate cancer. CPPS members have several vital accomplishments in these areas: developing a national research, training, and awareness network on Latino cancer;promoting tobacco prevention and cessation among children and Latinos; developing several patient navigation programs to increase Latino access to cancer care;testing video game technology to improve adherence to prescribed cancer treatment regimens for adolescents and young adults;assessing the relationship between obesity and childhood acute lymphoblastic leukemia in Latinos; creating a prostate cancer risk calculator tool;and identification of risk biomarkers for prostate and other cancers. Program members come from broad scientific backgrounds, such as behavioral science, epidemiology, basic science, chemoprevention, and others across many UTHSCSA departments and schools. CPPS researchers work collaboratively within the program and across the entire CTRC to translate their cancer prevention findings from the laboratory/clinic and population-based studies to bring improved methods of cancer reduction, early detection, diagnosis, treatment, and survival to South Texas and the nation. The program features severarmulti-Investigator projects, including a U10 and several U01 grants, as well as 42 overall projects, 19 of which are NCl-funded at more than $5.5 million in annual directs. Education and training is another important program component, both among membership (through regular CPPS member meetings and cancer prevention/control guest lecturers) and in projects, including several projects geared to training minorities in research and aiding their development in cancer-related fields at the doctoral level. In summary, the CPPS Program is a highly integrated multidisciplinary collaborative effort between diverse disciplines of scientists focused on cancer prevention and control.

Public Health Relevance

The CPPS Program is focused on cancer prevention through Innovative prevention and population science research, from reducing cancer-related health disparities (especially among minorities) to using cancer control to improve outcomes, and even identifying the determinants of cancer and cancer risk and prognosis. It is a vital part of the CTRC at UTHSCSA's commitment to reducing cancer and improving the health of patients across South Texas.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA054174-18
Application #
8107442
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
18
Fiscal Year
2010
Total Cost
$43,524
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Deng, Yilun; Qin, Yuejuan; Srikantan, Subramanya et al. (2018) The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet 27:1794-1808
Wei, Zhen; Panneerdoss, Subbarayalu; Timilsina, Santosh et al. (2018) Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing. Int J Genomics 2018:1351964
Chiang, Huai-Chin; Zhang, Xiaowen; Zhao, Xiayan et al. (2018) Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development. Sci Rep 8:2731
Zanotto-Filho, Alfeu; Rajamanickam, Subapriya; Loranc, Eva et al. (2018) Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells. Cancer Lett 425:101-115
Segovia, Jesus A; Chang, Te-Hung; Winter, Vicki T et al. (2018) NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection. Infect Immun 86:
Donegan, Jennifer J; Boley, Angela M; Lodge, Daniel J (2018) Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism. Neuropsychopharmacology 43:1789-1798
Vaidya, Anand; Flores, Shahida K; Cheng, Zi-Ming et al. (2018) EPAS1 Mutations and Paragangliomas in Cyanotic Congenital Heart Disease. N Engl J Med 378:1259-1261
Cepeda, Sergio; Cantu, Carolina; Orozco, Stephanie et al. (2018) Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens. Cell Rep 22:1276-1287
Snead, Wilton T; Zeno, Wade F; Kago, Grace et al. (2018) BAR scaffolds drive membrane fission by crowding disordered domains. J Cell Biol :
Ramasamy, Kumaraguruparan; Balasubramanian, Sowmya; Manickam, Krishnan et al. (2018) Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity. MBio 9:

Showing the most recent 10 out of 989 publications