The Bioinformatics Core Facility at the Robert H. Lurie Comprehensive Cancer Center is a new core and is focused on collaboration and publication with Cancer Center members. The Bioinformatics Core Facility members are defined as individuals performing bioinformatics, application development or data management activities on cancer projects. The Core Facility consists of five faculty-level bioinformaticists with an experienced and diverse staff supporting the fundamental activities of the Core. All Core Facility members are faculty or staff in the Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine with two faculty, Kibbe and Lin, also having appointments in the Center for Genetic Medicine in the Feinberg School of Medicine. For this CCSG renewal, the specific aims of the Core are to: 1. Provide bioinformatics services and educational opportunities to all Cancer Center Investigators. 2. Provide data handling and data services to Cancer Center members and Cores. 3. Provide molecular analysis services and common analysis platforms to Cancer Center members. 4. Provide computational services to Cancer Center members and Cores. 5. Support and enhance NOTIS, the Cancer Center's in house clinical trials management software. During the usage reporting period 08/01/05 - 07/31/06, the Core worked on at least 35 separate projects for at least 31 distinct users, 25 who are Center members. The Core has usage in all 10 Cancer Center programs and it interacts with several relevant Cores, particularly the Biostatistics Core Facility. The Core also participated in over 50 grant applications and Core members co-authored over 20 papers during the past five years. Over the next five years, the Core will continue to provide the Cancer Center with bioinformatics and computational support for molecular imaging, genomics, proteomics, clinical trials and clinical informatics. State of the art algorithms for pathway analysis, microarray analysis, proteomics, good software development practices, and data handling and computational resources will be available to Cancer Center members. Collaboration with the Biostatistics Core will continue to be strengthened, as faculty and staff in both Cores further develop their collaborative interests and funded projects. The Bioinformatics Core Facility will continue to respond to user requests for participation in grant applications, expand faculty and staff effort as needed to respond to the changing needs of funded grants, strive to maintain a revenue profile where funded grants represent the majority revenue sources relative to CCSG and institutional funds and strive to maintain the professional level of faculty and staff through their attendance at and participation in technical courses, training, and interaction with faculty throughout the institution and the world at conferences and meetings.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA060553-18S3
Application #
8486526
Study Section
Subcommittee G - Education (NCI)
Project Start
2012-09-06
Project End
2013-07-31
Budget Start
2012-09-06
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$175,046
Indirect Cost
$85,186
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Yan, M; Lewis, P L; Shah, R N (2018) Tailoring nanostructure and bioactivity of 3D-printable hydrogels with self-assemble peptides amphiphile (PA) for promoting bile duct formation. Biofabrication 10:035010
Edelbrock, Alexandra N; Àlvarez, Zaida; Simkin, Dina et al. (2018) Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor. Nano Lett 18:6237-6247
Fisher, Daniel W; Han, Ye; Lyman, Kyle A et al. (2018) HCN channels in the hippocampus regulate active coping behavior. J Neurochem 146:753-766
Sullivan, David P; Bui, Triet; Muller, William A et al. (2018) In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines. Mucosal Immunol 11:1571-1581
Russi, Abigail E; Ebel, Mark E; Yang, Yuchen et al. (2018) Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility. Proc Natl Acad Sci U S A 115:E1520-E1529
Frankowski, Kevin J; Wang, Chen; Patnaik, Samarjit et al. (2018) Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med 10:
Melo-Cardenas, Johanna; Xu, Yuanming; Wei, Juncheng et al. (2018) USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Blood 132:423-434
Sato, Tatsuya; Chang, Hsiang-Chun; Bayeva, Marina et al. (2018) mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function. Proc Natl Acad Sci U S A 115:E6291-E6300
Wiwatpanit, Teerawat; Lorenzen, Sarah M; Cantú, Jorge A et al. (2018) Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature 563:691-695
Spring, Bonnie; Pellegrini, Christine; McFadden, H G et al. (2018) Multicomponent mHealth Intervention for Large, Sustained Change in Multiple Diet and Activity Risk Behaviors: The Make Better Choices 2 Randomized Controlled Trial. J Med Internet Res 20:e10528

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