? QUANTITATIVE DATA SCIENCES CORE The Quantitative Data Sciences Core (QDSC) provides a state-of-the-art integrated approach for Data Science support to Lurie Cancer Center (LCC) members in the basic, clinical and population sciences. ?Data Sciences? includes the three disciplines of Biostatistics, Bioinformatics and Clinical Informatics. Since the last CCSG review, the former Biostatistics Core and Cancer Informatics Core have been integrated into a new QDSC to provide a unified approach to data definition, acquisition, management, analysis and reporting. The QDSC Director is Alfred Rademaker PhD; Associate Directors are Denise Scholtens PhD (Biostatistics), Matthew Schipma PhD (Bioinformatics) and Firas Wehbe MD,PhD (Clinical Informatics). As part of this consolidation, the core has been expanded through the addition of faculty and staff effort bridging the fields of informatics and statistics, areas of expertise often sought together by members of the LCC. The QDSC also works collaboratively with the Pathology Core Facility, the Outcomes Measurement and Survey Core, and the LCC Clinical Trials Office. The Biostatistics component provides power calculations and statistical analyses to investigators who are planning and conducting basic and preclinical studies and assists in the development of early phase and randomized clinical trials. The Bioinformatics component provides support for the analysis of next generation sequencing data, pathway identification, variant detection, methylation analysis, and data visualization. The Clinical Informatics component provides clinical trial management, disease-based database and informatics tools, project specific Research Electronic Data Capture (REDCap) development, pathology data management, and support for accessing and analyzing Northwestern Medicine Electronic Data Warehouse (NMEDW) data. QDSC Clinical Informatics has integrated and augmented the Northwestern Oncology Trial Information System (NOTIS), LCC?s clinical trial management system, and the electronic medical record (Epic) used by our clinical partners. QDSC has been heavily used by cancer researchers, with 109 LCC members using the Core in the last year, and it has been instrumental in the publication of 151 papers, many in high impact journals. Moreover, it has contributed to the success of many grant applications, notable among them a renewal of a SPORE in Prostate Cancer and a new U54 Chicago Collaborative to Promote and Advance Cancer Health Equity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA060553-24S2
Application #
9771914
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Ptak, Krzysztof
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hong, Bong Jin; Iscen, Aysenur; Chipre, Anthony J et al. (2018) Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability. J Phys Chem Lett 9:1133-1139
Smith, Erica D; Garza-Gongora, Arturo G; MacQuarrie, Kyle L et al. (2018) Interstitial telomeric loops and implications of the interaction between TRF2 and lamin A/C. Differentiation 102:19-26
Hsiao, Hsi-Min; Fernandez, Ramiro; Tanaka, Satona et al. (2018) Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1?. J Clin Invest 128:2833-2847
Mehta, Amol; Awah, Chidiebere U; Sonabend, Adam M (2018) Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy. Front Neurol 9:459
Brown, Jessica H; Das, Prativa; DiVito, Michael D et al. (2018) Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73:217-227
Ntai, Ioanna; Fornelli, Luca; DeHart, Caroline J et al. (2018) Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Proc Natl Acad Sci U S A 115:4140-4145
Malik, Neha; Iyamu, Iredia D; Scheidt, Karl A et al. (2018) Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity. Tetrahedron Lett 59:1513-1516
Wiwatpanit, Teerawat; Remis, Natalie N; Ahmad, Aisha et al. (2018) Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. J Neurosci 38:3177-3189
Ladomersky, Erik; Zhai, Lijie; Lenzen, Alicia et al. (2018) IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma. Clin Cancer Res 24:2559-2573
Wong, Yvette C; Ysselstein, Daniel; Krainc, Dimitri (2018) Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554:382-386

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