The Growth Factors &Signaling (GF) program is comprised of Members who focus on the central theme of signal transduction pathways relevant to cancer initiation, progression and metastasis. There are three goals that characterize this group: 1) study signaling pathways relevant to these three phases of oncogenesis, 2) develop new tools for the study of these signaling pathways, 3) develop compounds and strategies to target key components of these pathways, and 4) translate basic information into clinical applications. The GF Program has 29 Members, representing 12 Departments and five Schools, and has $5,602,675 in direct cancer-related peer-reviewed funding, 8 projects of which are funded by NCI for a direct total of $1,177,989. In 2007, Members published a total of 76 publications with 46 of those being cancer-related of which 28% were inter- and 9% were intra-related. This breadth is evident in three areas of study: Immune System and Cancer, Signaling in Epithelial Cancers, and Tools for Cancer Research and Therapeutics. Membership and GF activities have been reorganized over the past funding period. Program leadership changed to Dr. Marian L. Waterman and Dr. Nancy Allbritton in 2003, with a second change in leadership in 2007 when Dr. Christopher Hughes replaced Dr. Allbritton after her departure from UC Irvine. Membership has significantly changed since the last funding period with an active recruitment of Members from the bioengineering and chemistry disciplines and other Members moving to the Developmental Biology (DB) Program.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of California Irvine
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Carpenter, Philip M; Ziogas, Argyrios; Markham, Emma M et al. (2018) Laminin 332 expression and prognosis in breast cancer. Hum Pathol 82:289-296
Yan, Huaming; Romero-López, Mónica; Benitez, Lesly I et al. (2018) Multiscale modeling of glioblastoma. Transl Cancer Res 7:S96-S98
Yu, James; Landberg, Jenny; Shavarebi, Farbod et al. (2018) Bioengineering triacetic acid lactone production in Yarrowia lipolytica for pogostone synthesis. Biotechnol Bioeng 115:2383-2388
Oliver, Andrew; Kay, Matthew; Cooper, Kerry K (2018) Comparative genomics of cocci-shaped Sporosarcina strains with diverse spatial isolation. BMC Genomics 19:310
Mahlbacher, Grace; Curtis, Louis T; Lowengrub, John et al. (2018) Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment. J Immunother Cancer 6:10
Neek, Medea; Tucker, Jo Anne; Kim, Tae Il et al. (2018) Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. Biomaterials 156:194-203
McLelland, Bryce T; Lin, Bin; Mathur, Anuradha et al. (2018) Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci 59:2586-2603
Bota, Daniela A; Chung, Jinah; Dandekar, Manisha et al. (2018) Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol 7:CNS22
Han, Han; Qi, Ruxi; Zhou, Jeff Jiajing et al. (2018) Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell 72:328-340.e8
Solares, Edwin A; Chakraborty, Mahul; Miller, Danny E et al. (2018) Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. G3 (Bethesda) 8:3143-3154

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